J.E. Tanner
University of Melbourne
5 Papers
132 Citations
J.E. Tanner is an academic researcher from University of Melbourne. The author has contributed to research in topics: Amyloid precursor protein & Ectodomain. The author has an hindex of 5, co-authored 5 publications.
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Papers
Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice
Qiao-Xin Li,Christa J. Maynard,Roberto Cappai,Catriona McLean,Robert A. Cherny,Toni Lynch,Janetta G. Culvenor,Jim Trevaskis,J.E. Tanner,Karen Bailey,Christian Czech,Ashley I. Bush,Konrad Beyreuther,Colin L. Masters +13 more
TL;DR: This mouse model provides a system to study the intracellular processing and accumulation of Aβ or Aβ‐containing fragments and to screen for compounds directed at the γ‐secretase activity.
86
Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
D. Le Brocque,Anna Henry,Roberto Cappai,Qiao-Xin Li,J.E. Tanner,Denise Galatis,C Gray,S. Holmes,John R. Underwood,Konrad Beyreuther,Colin L. Masters,Genevieve Evin +11 more
TL;DR: Results suggest that the alpha-, beta-, and gamma-secretase cleavages are conserved in yeast and that P. pastoris may offer an alternative to mammalian cells to identify the proteases involved in the generation of AD betaA4 amyloid.
30
Products of the Alzheimer's disease amyloid precursor protein generated by,β-secretase are present in human platelets, and secreted upon degranulation
Qiao-Xin Li,Roberto Cappai,Genevieve Evin,J.E. Tanner,Carol W. Gray,Konrad Beyreuther,Colin L. Masters +6 more
TL;DR: Human platelets contain the a-, /3-and y-secretase activities, and are a suitable system to study APP processing and Ap production, a pathway which is considered to be a prime target for therapeutic intervention in AD.
11
Studies on inhibition of β-amyloid formation in APP-751-transfected IMR-32 cells, and SPA4CT-transfected SHSY5Y cells
David Allsop,Gary Christie,Gray Carol W,S. Holmes,R. Markwell,D. Owen,L. Smith,H. Wadsworth,Robin V. Ward,Tobias Hartmann,Stefan F. Lichtenthaler,Genevieve Evin,Stephanie J. Fuller,J.E. Tanner,C.L. Masters,Konrad Beyreuther,G. W. Roberts +16 more
- 01 Jan 1997
8
•Journal Article
Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets.
TL;DR: The release of platelet Abeta by physiologic stimuli suggests that it may play a role in platelet aggregation and coagulation or in the repair mechanisms associated with injury.