J. Collins
University of Birmingham
9 Papers
242 Citations
J. Collins is an academic researcher from University of Birmingham. The author has contributed to research in topics: Small intestine & Rotavirus. The author has an hindex of 8, co-authored 9 publications.
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Papers
An electron microscopic investigation of time-related changes in the intestine of neonatal mice infected with murine rotavirus.
Michael P. Osborne,S. J. Haddon,A. J. Spencer,J. Collins,W. G. Starkey,T. S. Wallis,G. J. Clarke,Kim J. Worton,D. C. A. Candy,John Stephen +9 more
TL;DR: It is suggested that many of the pathological features following rotav virus infection result from rotavirus-induced ischemia of villi and that diarrhea results from malabsorption of fluid by damaged villo and hypersecretion of ions released from increased numbers of dividing cells at villus-crypt borders.
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Intestinal enzyme profiles in normal and rotavirus-infected mice.
J. Collins,W. G. Starkey,T. S. Wallis,G. J. Clarke,Kim J. Worton,A. J. Spencer,S. J. Haddon,Michael P. Osborne,D. C. A. Candy,John Stephen +9 more
TL;DR: To investigate further the pathophysiology of rotav virus-induced diarrhea, changes in specific activities of eight relevant intestinal enzymes were measured following infection of suckling mice with murine rotavirus (epizootic diarrhea of infant mouse strain) and compared with age-matched control mice.
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Disaccharidase activities in small intestine of rotavirus-infected suckling mice: a histochemical study.
TL;DR: The timing and duration of diminished lactase activities were such that they were unlikely to cause the induction or perpetuation of diarrhea in murine rotavirus diarrhea and the location of enzyme activity to brush border regions rather than the cytoplasm of villus enterocytes enhances the significance of previous quantitative studies on these enzymes.
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X-ray microanalysis of rotavirus-infected mouse intestine: A new concept of diarrhoeal secretion
A. J. Spencer,Michael P. Osborne,S. J. Haddon,J. Collins,W. G. Starkey,D. C. A. Candy,John Stephen +6 more
TL;DR: A new concept of the pathophysiology of rotavirus-induced diarrhoeal secretion is proposed: stimulation of villus base cells to rapid cell division is accompanied by transient accumulation of Na and Cl; excess NaCl is secreted into the lumen, which is the driving force for fluid loss.
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Transport of water and electrolytes by rotavirus-infected mouse intestine: a time course study.
TL;DR: The present data are interpreted as evidence for a secretory component in rotavirus-induced diarrhea, and both the magnitude and statistical significance of changes in Na+ transport and the pattern of change was similar to that for Cl.
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