Ivan Gusarov
New York University
22 Papers
26 Citations
Ivan Gusarov is an academic researcher from New York University. The author has contributed to research in topics: Intrinsic termination & RNA polymerase. The author has an hindex of 15, co-authored 22 publications.
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Papers
Sensing Small Molecules by Nascent RNA: A Mechanism to Control Transcription in Bacteria
Alexander Mironov,Ivan Gusarov,Ruslan Rafikov,Lubov Errais Lopez,Konstantin Shatalin,R. A. Kreneva,D. A. Perumov,Evgeny Nudler +7 more
TL;DR: It is demonstrated that the feedback regulation of riboflavin and thiamin genes relies on a novel transcription attenuation mechanism that involves the formation of specific complexes between a conserved leader region of the cognate RNA and FMN or TPP.
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Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics
TL;DR: It is shown that NO generated by bNOS increases the resistance of bacteria to a broad spectrum of antibiotics, enabling the bacteria to survive and share habitats with antibiotic-producing microorganisms, and suggests that the inhibition of NOS activity may increase the effectiveness of antimicrobial therapy.
Bacterial Nitric Oxide Extends the Lifespan of C. elegans
Ivan Gusarov,Laurent Gautier,Olga Smolentseva,Ilya Shamovsky,Svetlana Eremina,Alexander Mironov,Evgeny Nudler +6 more
TL;DR: It is demonstrated that bacterially derived NO enhances C. elegans longevity and stress resistance via a defined group of genes that function under the dual control of HSF-1 and DAF-16 transcription factors.
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Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress.
Ivan Gusarov,Bibhusita Pani,Laurent Gautier,Olga Smolentseva,Svetlana Eremina,Ilya Shamovsky,Olga Katkova-Zhukotskaya,Alexander Mironov,Evgeny Nudler +8 more
TL;DR: G glycogen interferes with low insulin signalling and accelerates aging of long-lived daf-2 worms fed a high glucose diet, suggesting that glycogen metabolism might also have a role in mammalian aging.
Methicillin-resistant Staphylococcus aureus Bacterial Nitric-oxide Synthase Affects Antibiotic Sensitivity and Skin Abscess Development
Nina M. van Sorge,Federico C. Beasley,Ivan Gusarov,David Gonzalez,Maren von Köckritz-Blickwede,Sabina Anik,Andrew W. Borkowski,Pieter C. Dorrestein,Evgeny Nudler,Victor Nizet +9 more
TL;DR: The generated isogenic bNOS-deficient mutant in the epidemic community-acquired methicillin-resistant S. aureus USA300 clone showed reduced virulence with decreased survival and smaller abscess generation in a mouse subcutaneous infection model, indicating that bN OS contributes to MRSA innate immune and antibiotic resistance phenotypes.
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