Ivan Carcamo-Orive
Stanford University
25 Papers
141 Citations
Ivan Carcamo-Orive is an academic researcher from Stanford University. The author has contributed to research in topics: Insulin resistance & Biology. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Ivan Carcamo-Orive include Cardiovascular Institute of the South.
Chat about Author
Papers
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
Ivan Carcamo-Orive,Gabriel E. Hoffman,Paige Cundiff,Noam D. Beckmann,Sunita L. D’Souza,Joshua W. Knowles,Achchhe Patel,Dimitri Papatsenko,Dimitri Papatsenko,Fahim Abbasi,Gerald M. Reaven,Sean Whalen,Philip Lee,Mohammad Shahbazi,Marc Henrion,Kuixi Zhu,Sven Wang,Panos Roussos,Panos Roussos,Eric E. Schadt,Gaurav Pandey,Rui Chang,Thomas Quertermous,Ihor R. Lemischka +23 more
TL;DR: Network, pathway, and key driver analyses showed that Polycomb targets contribute significantly to the non-genetic variability seen within and across individuals, highlighting this chromatin regulator as a likely source of reprogramming-based variability.
266
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Joshua W. Knowles,Weijia Xie,Zhongyang Zhang,Indumathi Chennemsetty,Themistocles L. Assimes,Jussi Paananen,Ola Hansson,James S. Pankow,Mark O. Goodarzi,Ivan Carcamo-Orive,Andrew P. Morris,Yii-Der Ida Chen,Ville-Petteri Mäkinen,Andrea Ganna,Anubha Mahajan,Xiuqing Guo,Fahim Abbasi,Danielle M. Greenawalt,Pek Yee Lum,Cliona Molony,Lars Lind,Cecilia M. Lindgren,Leslie J. Raffel,Philip S. Tsao,Pacific Program for Hypertension,Eric E. Schadt,Jerome I. Rotter,Alan R. Sinaiko,Gerald M. Reaven,Xia Yang,Chao A. Hsiung,Leif Groop,Heather J. Cordell,Markku Laakso,Ke Hao,Erik Ingelsson,Timothy M. Frayling,Michael N. Weedon,Mark Walker,Thomas Quertermous +39 more
TL;DR: A genome-wide association study for direct measures of insulin sensitivity and the presence of a nonsynonymous variant of N-acetyltransferase 2 (NAT2) was strongly associated with decreased insulin sensitivity that was independent of BMI, supporting a role for NAT2 in insulin sensitivity.
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
Zewen Jiang,Meng Zhao,Laetitia Voilquin,Yunshin Jung,Mari Aikio,Tanushi Sahai,Florence Y. Dou,Alexander M. Roche,Ivan Carcamo-Orive,Joshua W. Knowles,Martin Wabitsch,Eric A. Appel,Caitlin L. Maikawa,Joao Paulo Camporez,Gerald I. Shulman,Linus T.-Y. Tsai,Evan D. Rosen,Christopher D. Gardner,Bruce M. Spiegelman,Katrin J. Svensson +19 more
TL;DR: In this article, the authors identify isthmin-1 (Ism1) as an adipokine and one that has a dual role in increasing adipose glucose uptake while suppressing hepatic lipid synthesis.
78
Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk.
Ivan Carcamo-Orive,Ainhoa Gaztelumendi,Jesús Delgado,Naiara Tejados,Akaitz Dorronsoro,Jon Fernández-Rueda,Daniel J. Pennington,César Trigueros +7 more
TL;DR: A novel c‐Jun‐centered regulatory network of signaling pathways in differentiating hBMSCs that controls the proliferation‐dependent balance between osteogenesis and adipogenesis is revealed.
76
Erratum: Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene (American Society for Clinical Investigation (2015)125:4 (1739-1751) DOI 10.1172/JCI74692)
Joshua W. Knowles,Weijia Xie,Zhongyang Zhang,Indumathi Chennamsetty,Themistocles L. Assimes,Jussi Paananen,Ola Hansson,James S. Pankow,Mark O. Goodarzi,Ivan Carcamo-Orive,Andrew P. Morris,Yii-Der Ida Chen,Ville-Petteri Mäkinen,Andrea Ganna,Anubha Mahajan,Xiuqing Guo,Fahim Abbasi,Danielle M. Greenawalt,Pek Yee Lum,Cliona Molony,Lars Lind,Cecilia M. Lindgren,Leslie J. Raffel,Philip S. Tsao,Eric E. Schadt,Jerome I. Rotter,Alan R. Sinaiko,Gerald M. Reaven,Xia Yang,Chao A. Hsiung,Leif Groop,Heather J. Cordell,Markku Laakso,Ke Hao,Erik Ingelsson,Timothy M. Frayling,Michael N. Weedon,Mark Walker,Thomas Quertermous +38 more
TL;DR: A genome-wide association study for direct measures of insulin sensitivity and the presence of a nonsynonymous variant of N-acetyltransferase 2 (NAT2) was strongly associated with decreased insulin sensitivity that was independent of BMI, supporting a role for NAT2 in insulin sensitivity.