Itay Shafat
Technion – Israel Institute of Technology
12 Papers
80 Citations
Itay Shafat is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Heparanase & Heparan sulfate. The author has an hindex of 7, co-authored 12 publications.
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Papers
Age-Related Changes in Salivary Antioxidant Profile: Possible Implications for Oral Cancer
TL;DR: Salivary oxidative stress-related changes in the intimately related saliva and oral epithelium compounded with higher viscosity of saliva may explain the higher prevalence of oral cancer in the elderly population.
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis
Nicola J. Nasser,Aaron Avivi,Itay Shafat,Evgeny Edovitsky,Eyal Zcharia,Neta Ilan,Israel Vlodavsky,Eviatar Nevo +7 more
TL;DR: The cloning of a unique splice variant (splice 36) of heparanase from the subterranean blind mole rat (Spalax) is reported, demonstrating that alternative splicing of heParanase regulates its enzymatic activity and might adapt the heparinase function to the fluctuating normoxic–hypoxic subterranean environment that Spalax experiences.
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Adaptive evolution of heparanase in hypoxia-tolerant Spalax: Gene cloning and identification of a unique splice variant
TL;DR: The cloning of heparanase from four Israeli species of the blind subterranean mole rat (Spalax ehrenbergi superspecies), 85% homologous to the human enzyme is reported, indicating a possible role in adaptation to stress in Spalax evolution.
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Heparanase up-regulation in tongue cancer: tissue and saliva analysis.
Rafael M. Nagler,Ofer Ben-Izhak,Victoria Cohen-Kaplan,Itay Shafat,Israel Vlodavsky,Sharon Akrish,Neta Ilan +6 more
TL;DR: Heparanase up‐regulation has been correlated with reduced postoperative survival in various cancers and should be considered as a clinical indication for further research.
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PLASMA HEPARANASE AS A SIGNIFICANT MARKER OF TREATMENT RESPONSE IN CHILDREN WITH HODGKIN LYMPHOMA: Pilot Study
TL;DR: Changes in plasma HP levels correlated with response to treatment for children diagnosed with Hodgkin lymphoma and provides a rationale for exploring clinical interest in plasma heparanase measurements of a larger group, using the test for clinical trials of antiangiogenic therapies.
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