István Timári
University of Debrecen
42 Papers
290 Citations
István Timári is an academic researcher from University of Debrecen. The author has contributed to research in topics: Chemistry & Heteronuclear single quantum coherence spectroscopy. The author has an hindex of 11, co-authored 30 publications. Previous affiliations of István Timári include Ohio State University.
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Papers
?Perfecting? pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings
Lukas Kaltschnee,Andreas Kolmer,István Timári,Volker Schmidts,Ralph W. Adams,Mathias Nilsson,Mathias Nilsson,Katalin E. Kövér,Gareth A. Morris,Christina M. Thiele +9 more
TL;DR: It is shown that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.
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Accurate determination of one-bond heteronuclear coupling constants with “pure shift” broadband proton-decoupled CLIP/CLAP-HSQC experiments
István Timári,Lukas Kaltschnee,Andreas Kolmer,Ralph W. Adams,Mathias Nilsson,Christina M. Thiele,Gareth A. Morris,Katalin E. Kövér +7 more
TL;DR: In this article, a broadband proton-decoupled CLIP/CLAP-HSQC experiments were conducted for the accurate determination of one-bond heteronuclear couplings and for the reliable measurement of small residual dipolar coupling constants.
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Real-time pure shift 15N HSQC of proteins: a real improvement in resolution and sensitivity
Peter Kiraly,Ralph W. Adams,Liladhar Paudel,Liladhar Paudel,Mohammadali Foroozandeh,Juan A. Aguilar,István Timári,Matthew J. Cliff,Mathias Nilsson,Péter Sándor,Gyula Batta,Jonathan P. Waltho,Katalin E. Kövér,Gareth A. Morris +13 more
TL;DR: Several novel pure shift experiments are presented, and the improvements in resolution and sensitivity they provide are evaluated for representative samples: the N-terminal domain of PGK; ubiquitin; and two mutants of the small antifungal protein PAF.
Synthesis and anticoagulant activity of bioisosteric sulfonic-Acid analogues of the antithrombin-binding pentasaccharide domain of heparin.
Mihály Herczeg,László Lázár,Zsuzsanna Bereczky,Katalin E. Kövér,István Timári,János Kappelmayer,András Lipták,Sándor Antus,Anikó Borbás +8 more
TL;DR: In vitro evaluation of the anticoagulant activity of these new sulfonic-acid derivatives revealed that the disulfonate analogue inhibited the blood-coagulation-proteinase factor Xa with outstanding efficacy; however, the introduction of the third sulfonate moiety resulted in a notable decrease in the anti-Xa activity.
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PSYCHE CPMG–HSQMBC: An NMR Spectroscopic Method for Precise and Simple Measurement of Long‐Range Heteronuclear Coupling Constants
TL;DR: A broadband homonuclear decoupled PSYCHE CPMG-HSQMBC method for the precise and direct measurement of multiple-bond heteronuclear couplings is presented and can provide significant improvement in sensitivity as compared to an earlier Zangger-Sterk-based method.
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