El sindrome de Brugada, descrito por primera vez en 1992, se caracteriza por un patron electrocardiografico caracteristico en precordiales derechas y la predisposicion a presentar arritmias ventriculares y muerte subita. El sindrome de Brugada se incluye entre las canalopatias, trastornos electricos primarios que caracteristicamente no asocian cardiopatia estructural concomitante. En los ultimos anos, gracias a una intensa labor cientifica tanto basica como clinica, hemos podido identificar multiples mutaciones causales, y asimismo comprender cuales son los mecanismos implicados en la aparicion del fenotipo caracteristico y los determinantes del pronostico clinico en los pacientes. Sin embargo, todavia persisten multiples preguntas sin resolver que mantienen activa la investigacion sobre el tema. Este articulo revisa nuestro conocimiento actual sobre el sindrome de Brugada y trata de recoger los principales estudios basicos y clinicos que han contribuido mas significativamente a avanzar en nuestra comprension de esta enfermedad.

http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/download/498/425

Síndrome de Brugada

https://www.amjmed.com/article/S0002-9343(01)00625-8/pdf

The Brugada syndrome: clinical, genetic, cellular, and molecular abnormalities

https://www.internationaljournalofcardiology.com/article/S0167-5273(05)00914-9/pdf

Arrhythmogenic right ventricular dysplasia/cardiomyopathy. A review and update

Molecular genetic basis of sudden cardiac death.

We present the case of a 60-year-old female patient who had been in menopause for 14 years and presented a pulmonary nodule on chest X-ray diagnosed in the postoperative follow-up evaluation of breast cancer. The patient had a history of mastectomy and ipsilateral axillary lymphadenectomy for invasive ductal breast carcinoma, as well as of hormone therapy, chemotherapy, and adjuvant radiotherapy. After thoracoscopic nodulectomy, the frozen section analysis revealed a pulmonary hamartoma. Recent studies show that 75% of patients who undergo surgery for pulmonary nodules after a curative mastectomy for breast cancer present lung metastases, 11.5% present primary lung cancer, and 13.5% present benign lesions, including hamartoma.

Relato de caso

La sus-denivellation non coronaire du segment ST en precordiales droites a ete decrite chez des sujets ayant presente des episodes de fibrillation ventriculaire au repos. Ce syndrome a ete rapporte a des phenomenes fonctionnels ou a des anomalies structurelles du myocarde. Un cas personnel montre son appartenance aux deux categories : la sus-denivellation du segment ST observee avant, pendant et apres des episodes de trouble du rythme est comparee a Il electrocardiogrammes de la litterature. La dysplasie du ventricule droit est demontree par l'electrocardiographie, l'electrophysiologie et l'echocardiographie. D'autre part, la sus-denivellation du segment ST est classee en trois categories : les formes triangulaire et en dome sont le plus souvent observees au moment des troubles du rythme, la derniere « en selle », jusqu'ici non decrite, apparait comme un equivalent mineur observe en dehors des episodes critiques. Ce dernier aspect est retrouve chez 30 % des cas de dysplasie ventriculaire droite arythmogene cliniquement identifies.

Right precordial leads and sudden death. Relation with arrhythmogenic right ventricular dysplasia

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Right precordial leads and sudden death. Relation with arrhythmogenic right ventricular dysplasia