Isis Paez
University of La Frontera
6 Papers
3 Citations
Isis Paez is an academic researcher from University of La Frontera. The author has contributed to research in topics: Medicine & Atorvastatin. The author has an hindex of 1, co-authored 2 publications.
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Papers
Atorvastatin Increases the Expression of Long Non-Coding RNAs ARSR and CHROME in Hypercholesterolemic Patients: A Pilot Study.
TL;DR: The results indicate that atorvastatin modulates the expression of cholesterol-related lncRNAs differentially, suggesting that these molecules play a role in the variability of response to this drug; however, additional studies are needed to disclose the implication of this differential regulation on statin response.
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MicroRNA-33b is a Potential Non-Invasive Biomarker for Response to Atorvastatin Treatment in Chilean Subjects With Hypercholesterolemia: A Pilot Study.
Carmen Gloria Ubilla,Yalena Prado,Jeremy Angulo,Ignacio Obreque,Isis Paez,Nicolás Saavedra,Kathleen Saavedra,Tomás Zambrano,Luis A. Salazar +8 more
TL;DR: Comision Nacional de Investigacion Cientificifica y Tecnologica (CONICYT)================== CONICYTE-FONDECYT FONDECI-TEECHNOLOGIA (CTTE-FITE) as discussed by the authors )
MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis
Pía Loren,Yuliannis Lugones,Nicolás Saavedra,Kathleen Francinette Saavedra,Isis Paez,Nelia Rodríguez,Patricia Moriel,Luis A. Salazar +7 more
TL;DR: In this article , the authors describe how different miRNAs regulate some pathways leading to cell death by apoptosis, specifically the intrinsic apoptosis pathway, which is presented as a side effect of antineoplastic treatment.
MicroRNA-20a-5p Downregulation by Atorvastatin: A Potential Mechanism Involved in Lipid-Lowering Therapy
Kathleen Francinette Saavedra,Karla Zimpel Leal,Nicolás Saavedra,Yalena Prado,Isis Paez,Carmen Gloria Ubilla,Gabriel Rojas,Luis A. Salazar +7 more
TL;DR: Repression of hsa-mir-20a-5p increased LDLR gene and protein expression in HepG2 cells, while hsa/miR overexpression reduced cholesterol-lowering genes andprotein expression and miRNA hsa://mir- 20a- 5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in Hep G2 cells in culture.
Cholesterol-Related lncRNAs as Response Predictors of Atorvastatin Treatment in Chilean Hypercholesterolemic Patients: A Pilot Study
TL;DR: In this article , the levels of expression of three lncRNAs (RP1-13D10.2, MANTIS, lncHR1) associated with genes involved in cholesterol homeostasis in leukocyte cells of hypercholesterolemic patients after treatment with atorvastatin and compare them with levels in subjects with normal cholesterol levels.