Resume Objectif : Preciser les parametres mecaniques du couplage contraction-relaxation en condition isotonique et isometrique des muscles squelettiques de sujets non sensibles et sensibles a l’hyperthermie maligne (HM). Type d’etude : Etude de laboratoire. Materiel et methodes : Lambeaux musculaires de 14 patients exposes a l’halothane 3 vol % pendant dix minutes, dont six ont ete diagnostiques sensibles a l’HM. Les parametres mecaniques de contraction et de relaxation ont ete calcules. Les vitesses maximales de la contraction (maxVc), de relaxation (maxVr) et les pics positif (+ dP/dtmax) et negatif (-dP/dtmax) de la derivee de la force isometrique ont ete calcules. Deux coefficients R1 = (maxVc) (maxVr) et R2 = (+ dP/dtmax) (-dP/dtmax) qui evaluent le couplage contraction-relaxation en isotonie et en isometrie ont ete respectivement calcules. Resultats : Sur les muscles non sensibles a l’HM, l’halothane augmentait proportionnellement les parametres de contraction et de relaxation, par consequent les coefficients R1 et R2 restaient inchanges. En revanche, sur les muscles sensibles a l’HM, l’halothane provoquait une diminution significative des parametres de relaxation sans affecter significativement les parametres de contraction, de ce fait les coefficients R1 et R2 etaient augmentes (p  Conclusion : L’etude a montre que sur le muscle non sensible a l’HM, l’halothane ameliorait sur l’ensemble du parcours mecanique (isotonie et isometrie) les proprietes contractiles des muscles squelettiques. En revanche, sur le muscle sensible a l’HM, un effondrement des indices mecaniques de la relaxation en isotonie et en isometrie a ete observe. Cela est en faveur d’une anomalie des systemes membranaires en particulier du recaptage du calcium par le reticulum sarcoplasmique.

Étude du couplage contraction-relaxation du muscle squelettique de patients susceptibles à l'hyperthermie maligne

Shortening velocity of skeletal muscle from humans with malignant hyperthermia susceptibility: effects of halothane

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Shortening velocity of skeletal muscle from humans with malignant hyperthermia susceptibility: effects of halothane