Isabelle Schmutz
University of Fribourg
22 Papers
86 Citations
Isabelle Schmutz is an academic researcher from University of Fribourg. The author has contributed to research in topics: Circadian clock & CLOCK. The author has an hindex of 16, co-authored 22 publications. Previous affiliations of Isabelle Schmutz include University of Bern & Rockefeller University.
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Papers
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Gabriele Hampp,Jürgen A. Ripperger,Thijs Houben,Isabelle Schmutz,Christian Blex,Stephanie Perreau-Lenz,Irene Brunk,Rainer Spanagel,Gudrun Ahnert-Hilger,Johanna H. Meijer,Urs Albrecht +10 more
TL;DR: A role of circadian-clock components in dopamine metabolism highlighting a role of the clock in regulating mood-related behaviors is suggested.
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The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors
TL;DR: It is shown that the core loop component PER2 can coordinate circadian output with the circadian oscillator and may propagate clock information to metabolic pathways via nuclear receptors, adding an important facet to the clock-dependent regulation of biological networks.
The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.
Anna Schnell,Sylvie Chappuis,Isabelle Schmutz,Emanuele Brai,Jürgen A. Ripperger,Olivier Schaad,Hans Welzl,Patrick Descombes,Lavinia Alberi,Urs Albrecht +9 more
TL;DR: An important role of Rev-erbα and Fabp7 in adult neurogenesis is suggested, which may open new avenues for treatment of gliomas as well as neurological diseases such as depression and Alzheimer.
TRF2 binds branched DNA to safeguard telomere integrity.
TL;DR: It is proposed that TRF2 masks and stabilizes the t-loop three-way junction, thereby protecting telomeres from detrimental deletions and PARP1 activation and demonstrating the in vivo relevance of branched-DNA binding.
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The role of clock genes and rhythmicity in the liver.
TL;DR: This work focuses on the input and output pathways of the hepatic circadian oscillator and discusses the recently found flexibility of its circadian transcriptional networks.
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