Isabelle Salmon
Université libre de Bruxelles
394 Papers
3.3K Citations
Isabelle Salmon is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 61, co-authored 375 publications. Previous affiliations of Isabelle Salmon include Catholic University of Leuven & Free University of Brussels.
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Papers
Identification of the tumour transition states occurring during EMT
Ievgenia Pastushenko,Audrey Brisebarre,Alejandro Sifrim,Alejandro Sifrim,Marco Fioramonti,Tatiana Revenco,Soufiane Boumahdi,Alexandra Van Keymeulen,Daniel Brown,Virginie Moers,Sophie Lemaire,Sarah De Clercq,Esmeralda Minguijón,Cédric Balsat,Youri Sokolow,Christine Dubois,Florian De Cock,Samuel Scozzaro,Federico Sopena,Angel Lanas,Nicky D'Haene,Isabelle Salmon,Jean-Christophe Marine,Thierry Voet,Thierry Voet,Panagiota A. Sotiropoulou,Cédric Blanpain +26 more
TL;DR: A large panel of cell surface markers in skin and mammary primary tumours is screened, and the existence of multiple tumour subpopulations associated with different EMT stages are identified: from epithelial to completely mesenchymal states, passing through intermediate hybrid states.
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SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
Soufiane Boumahdi,Gregory Driessens,Gaëlle Lapouge,Sandrine Rorive,Dany Nassar,Marie Le Mercier,Benjamin Delatte,Amélie Caauwe,Sandrine Lenglez,Erwin Nkusi,Sylvain Brohée,Isabelle Salmon,Christine Dubois,Véronique Del Marmol,François Fuks,Benjamin Beck,Cédric Blanpain +16 more
TL;DR: It is demonstrated that SOX2, by marking and regulating the functions of skin tumour-initiating cells and CSCs, establishes a continuum between tumour initiation and progression in primary skin tumours.
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Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Ievgenia Pastushenko,Federico Mauri,Yura Song,Frédérique De Cock,Bob Meeusen,Benjamin Swedlund,Francis Impens,Delphi Van Haver,Matthieu Opitz,Manuel Théry,Manuel Théry,Yacine Bareche,Gaëlle Lapouge,Marjorie Vermeersch,Yves-Remi Van Eycke,Cédric Balsat,Christine Decaestecker,Youri Sokolow,Sergio Hassid,Alicia Perez-Bustillo,Beatriz Agreda-Moreno,L. Ríos-Buceta,Pedro Jaén,Pedro Redondo,Ramon Sieira-Gil,Jose Jf Millan-Cayetano,Onofre Sanmatrtin,Nicky D'Haene,Virginie Moers,Milena Rozzi,Jeremy Blondeau,Sophie Lemaire,Samuel Scozzaro,Veerle Janssens,Magdalena De Troya,Christine Dubois,David Perez-Morga,Isabelle Salmon,Christos Sotiriou,Françoise Helmbacher,Cédric Blanpain +40 more
TL;DR: Using mouse models of skin squamous cell carcinoma and lung tumours, it is found that deletion of Fat1 accelerates tumour initiation and malignant progression and promotes a hybrid epithelial-to-mesenchymal transition (EMT) phenotype.
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Alexandra Van Keymeulen,May Yin Lee,Marielle Ousset,Sylvain Brohée,Sandrine Rorive,Rajshekhar R. Giraddi,Aline Wuidart,Gaëlle Bouvencourt,Christine Dubois,Isabelle Salmon,Christos Sotiriou,Wayne A. Phillips,Wayne A. Phillips,Cédric Blanpain +13 more
TL;DR: This study identifies the cellular origin of Pik3ca-induced tumours and reveals that oncogenic Pik3CAH1047R activates a multipotent genetic program in normally lineage-restricted populations at the early stage of tumour initiation, setting the stage for future intratumoural heterogeneity.
Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.
Myriam Remmelink,Ricardo De Mendonça,Nicky D'Haene,Sarah De Clercq,Camille Verocq,Laetitia Lebrun,Philomène Lavis,Marie Lucie Racu,Anne-Laure Trepant,Calliope Maris,Sandrine Rorive,Jean-Christophe Goffard,Olivier De Witte,Lorenzo Peluso,Jean Louis Vincent,Christine Decaestecker,Fabio Silvio Taccone,Isabelle Salmon +17 more
TL;DR: A great heterogeneity of COVID-19-associated organ injury and the remarkable absence of any specific viral lesions, even when RT-PCR identified the presence of the virus in many organs are revealed.