Isabelle Menguy
4 Papers
8 Citations
Isabelle Menguy is an academic researcher. The author has contributed to research in topics: KRAS & Biology. The author has an hindex of 2, co-authored 3 publications.
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Papers
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Malvika Koundinya,Judith Sudhalter,Albane Courjaud,Bruno Lionne,Gaetan Touyer,Luc Bonnet,Isabelle Menguy,Isabelle Schreiber,Christelle Perrault,Stephanie Vougier,Brigitte Benhamou,Bailin Zhang,Timothy He,Qiang Gao,Patricia Gee,Daniel Simard,M. Paola Castaldi,Ronald Tomlinson,Stephan Reiling,Matthieu Barrague,Richard Newcombe,Hui Cao,Yanjun Wang,Fangxian Sun,Joshua Murtie,Mark Munson,Eric Yang,David Harper,Monsif Bouaboula,Jack Pollard,Claudine Grepin,Carlos Garcia-Echeverria,Hong Cheng,Francisco Adrian,Christopher Winter,Stuart Licht,Ivan Cornella-Taracido,Rosalia Arrebola,Aaron J. Morris +38 more
TL;DR: A high-throughput synthetic lethal screen for small molecules that selectively inhibit the growth of KRAS mutant cell lines in soft agar is reported, identifying the target of the most KRAS-selective chemical series as dihydroorotate dehydrogenase (DHODH).
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Direct Measurement of Multiple mRNAs in Nerve Growth Factor-Induced PC12 Cells Using Electrophoretic Tags to Monitor Biomarkers of Neuronal Differentiation in 96-Well Format
Pascale Roux,Isabelle Menguy,Stéphane Soubigou,Jason Chinn,Sylvain Ricard,Stephen Williams,Jean-Dominique Guitton,Tina Tian,Sharat Singh,Claudine Grepin +9 more
TL;DR: The experimental data shown here demonstrate the use of eTag technology as a new screening tool, which uniquely combines robustness, sensitivity, multiplexing capability, and direct measurement of mRNA without any sample preparation steps, such as RNA extraction/purification or a reverse transcription step.
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Abstract 2243: Clonogenic 3D high throughput screening in mutant KRAS dependent cancer cells - a chemogenomic approach.
Malvika Koundinya,Judith Sudhalter,Albane Courjaud,Bruno Lionne,Gaetan Touyer,Luc Bonnet,Isabelle Menguy,Isabelle Schreiber,Christelle Perrault,Stephanie Vougier,Brigitte Benhamou,Daniel Simard,Maria Paola Castaldi,Ronald Tomlinson,Stephan Reiling,Hui Cao,David P. Harper,Monsif Bouaboula,Jack Pollard,Claudine Grepin,Carlos Garcia-Echeverria,Francisco Adrian,Ivan Cornella-Taracido,Rosalia Arrebola,Aaron J. Morris +24 more
TL;DR: A multi-cell line parallel phenotypic high throughput screen with a proprietary compound collection has led to the identification of several chemical classes that inhibit the growth of multiple mutant KRAS cell lines of pancreatic and colorectal carcinoma origin, while sparing multiple wild-type KRAS cancer cell lines.
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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models
Stephane Illiano,B. Poirier,Claire Minoletti,Olivier Pasquier,L. Riva,Xavier Chénédé,Isabelle Menguy,Michel Guillotel,Philippe Prigent,Stéphane Le Claire,Florence Gillot,Gilbert Thill,François Lo Presti,Alain Cribier,Jean-Christophe Le Bail,P Grailhe,Edith Monteagudo,Raffaele Ingenito,Elisabetta Bianchi,Christophe Philippo,Olivier Duclos,Sergio Mallart,Ross A. D. Bathgate,Philip Janiak +23 more
TL;DR: In this paper , a single-chain lipidated peptide agonists of RXFP1 like SA10SC-RLX with subcutaneous bioavailability and extended half-life was identified.