Isabelle Duplan
Pasteur Institute
10 Papers
6 Citations
Isabelle Duplan is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Chemistry & Internal medicine. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Isabelle Duplan include Lille University of Science and Technology & French Institute of Health and Medical Research.
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Papers
The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis
Nathalie Hennuyer,Isabelle Duplan,Charlotte Paquet,Jonathan Vanhoutte,Eloise Woitrain,Véronique Touche,Sophie Colin,Emmanuelle Vallez,Sophie Lestavel,Philippe Lefebvre,Bart Staels +10 more
TL;DR: These results demonstrate that the novel selective PPARα modulator pemafibrate exerts beneficial effects on lipid metabolism, RCT and inflammation resulting in anti-atherogenic properties.
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
Manuel Lasalle,Vanessa Hoguet,Nathalie Hennuyer,Florence Leroux,Catherine Piveteau,Loic Belloy,Sophie Lestavel,Emmanuelle Vallez,Emilie Dorchies,Isabelle Duplan,Emmanuel Sevin,Maxime Culot,Fabien Gosselet,Rajaa Boulahjar,Adrien Herledan,Bart Staels,Benoit Deprez,Anne Tailleux,Julie Charton +18 more
TL;DR: Among them, compound 24 is a potent GLP-1 secretagogue, has low effect on gallbladder volume, and improves glucose homeostasis in a preclinical murine model of diet-induced obesity and insulin resistance, making the proof of concept of the potential of topical intestinal TGR5 agonists as therapeutic agents in type-2 diabetes.
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation
Rémy Bosviel,Rémy Bosviel,Laurie Joumard-Cubizolles,Laurie Joumard-Cubizolles,Giulia Chinetti-Gbaguidi,Giulia Chinetti-Gbaguidi,Dominique Bayle,Dominique Bayle,Corinne Copin,Nathalie Hennuyer,Isabelle Duplan,Bart Staels,Giuseppe Zanoni,Alessio Porta,Laurence Balas,Jean-Marie Galano,Camille Oger,Andrzej Mazur,Andrzej Mazur,Thierry Durand,Cécile Gladine,Cécile Gladine +21 more
TL;DR: The results show that neuro Prostanes and more especially cyclopentenone neuroprostanes have potent anti‐inflammatory activities similar or even more pronounced than protectins supporting that neuroProstanes should be considered as important contributors to the anti-inflammatory effects of DHA.
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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet,Manuel Lasalle,Mathieu Maingot,Geoffroy Dequirez,Rajaa Boulahjar,Florence Leroux,Catherine Piveteau,Adrien Herledan,Alexandre Biela,Julie Dumont,Oscar Chávez-Talavera,Loic Belloy,Isabelle Duplan,Nathalie Hennuyer,Laura Butruille,Sophie Lestavel,Emmanuel Sevin,Maxime Culot,Fabien Gosselet,Bart Staels,Benoit Deprez,Anne Tailleux,Julie Charton +22 more
TL;DR: In this article, the authors performed the conjugation of polyethylene glycols (220-5000 Da) to a series of non-steroidal small agonists of the bile acids receptor TGR5.
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Anti-inflammatory effects and improved metabolic derangements in ob/ob mice by a newly synthesized prenylated benzopyran with pan-PPAR activity.
Patrice Marques,Carlos Villarroel-Vicente,Aida Elena García del Collado,Ainhoa García,Laura Vila,Isabelle Duplan,Nathalie Hennuyer,F. Garibotto,Ricardo D. Enriz,Catherine Dacquet,Bart Staels,Laura Piqueras,Diego Cortes,Maria-Jesus Sanz,Nuria Cabedo +14 more
TL;DR: In this article , a new prenylated benzopyran (BP-2) was synthesized and evaluated its PPAR-activating properties, anti-inflammatory effects and impact on metabolic derangements.
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