Isabelle Cantaloube
Université Paris-Saclay
9 Papers
28 Citations
Isabelle Cantaloube is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Isabelle Cantaloube include French Institute of Health and Medical Research & University of Paris-Sud.
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Papers
Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues
Ariane Dimitrov,Mélanie Quesnoit,Mélanie Quesnoit,Sandrine Moutel,Isabelle Cantaloube,Christian Poüs,Franck Perez +6 more
TL;DR: Observations in living cells suggested that GTP remnants may be responsible for the rescue events in which microtubules recover from catastrophe, and a recombinant antibody was selected that specifically recognizes GTP-bound tubulin in micro Tubules and found that G TP-tubulin was indeed present at the plus end of growing microtubule.
294
Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation
Camille Geeraert,Ameetha Ratier,Simon G. Pfisterer,Daniel Perdiz,Isabelle Cantaloube,Audrey Rouault,Sophie Pattingre,Tassula Proikas-Cezanne,Patrice Codogno,Christian Poüs +9 more
TL;DR: The results show that the dynamics of microtubules and tubulin post-translational modifications play a major role in the regulation of starvation-induced autophagy.
196
Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser1177 occurs in a stable microtubule- and tubulin acetylation-dependent manner
Julien Giustiniani,S Couloubaly,Anita Baillet,Marie-Luce Pourci,Isabelle Cantaloube,C Fourniat,Jean-Louis Paul,Christian Poüs +7 more
TL;DR: It is shown that the involvement of stable microtubules in basal eNOS phosphorylation involved alpha-tubulin acetylation, and microtubule-dependent organization of subcellular eN OS and control over its phosphorylated would thus be essential for endothelial cells to maintain their basal e NOS function.
19
Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
Hélène Henrie,Dalal Bakhos-Douaihy,Isabelle Cantaloube,Antoine Pilon,Antoine Pilon,Maya Talantikite,Virginie Stoppin-Mellet,Anita Baillet,Christian Poüs,Christian Poüs,Béatrice Benoit +10 more
TL;DR: Upon stress, JNK stimulates microtubule dynamics in human epithelial cell lines and phosphorylates the rescue factor CLIP-170, increasing its retention frequency on the lattice behind comets, at locations that correspond to potential future rescue sites.
Septin filament coalignment with microtubules depends on SEPT9_i1 and tubulin polyglutamylation, and is an early feature of acquired cell resistance to paclitaxel.
Benjamin Targa,Laurence Klipfel,Isabelle Cantaloube,Joëlle Salameh,Béatrice Benoit,Christian Poüs,Anita Baillet +6 more
TL;DR: Coupling septins (including SEPT9_i1) overexpression together with long-chain tubulin polyglutamylation induce significant paclitaxel resistance in several naive (taxane-sensitive) cell lines and accordingly stimulate the binding of CLIP-170 and MCAK to microtubules.