Isabelle Bar
12 Papers
5 Citations
Isabelle Bar is an academic researcher. The author has contributed to research in topics: Breast cancer & Triple-negative breast cancer. The author has an hindex of 6, co-authored 8 publications.
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Papers
TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma.
Brenda De Keersmaecker,Sofie Claerhout,Javier Carrasco,Isabelle Bar,Jurgen Corthals,Sofie Wilgenhof,Bart Neyns,Kris Thielemans +7 more
TL;DR: The levels of polyfunctional and multiantigen T-cell responses measured in patients with a complete response, particularly in patients evidently cured after 5+ years of follow-up, may provide a benchmark for the level of immune stimulation needed to achieve a durable clinical remission.
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Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer
Sébastien Toffoli,Isabelle Bar,Fadi Abdel-Sater,Paul Delrée,Pascale Hilbert,Frédéric Cavallin,Fabrice Moreau,Wim Van Criekinge,Magali Lacroix-Triki,Mario Campone,Anne-Laure Martin,Henri Roché,Jean-Pascal Machiels,Javier Carrasco,Jean-Luc Canon +14 more
TL;DR: This study has identified by array CGH and confirmed by FISH a recurrent gain in 17q25.3 significantly associated to BRCA1 mutated TNBC, which might represent potential therapeutic targets and warrant further investigation.
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The MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer.
Isabelle Bar,Ahmad Merhi,Fadi Abdel-Sater,Abduelhakem Ben Addi,Sara Sollennita,Jean-Luc Canon,Paul Delrée +6 more
TL;DR: The results demonstrate that miR-210 is expressed in tumor cells but also in the tumor microenvironment, and highlight the utility of using complementary approaches to take into account the cellular context of microRNA expression.
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Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma
Didier Dequanter,Maureen Van de Velde,Isabelle Bar,Vincent Nuyens,Alexandre Rousseau,Nathalie Nagy,Luc Vanhamm,Michel Vanhaeverbeek,Dany Brohée,Paul Delrée,Karim Zouaoui Boudjeltia,Philippe Lothaire,Pierrick Uzureau +12 more
TL;DR: Increased expression of GCL and the rate-limiting enzyme of GSH synthesis, within HNSCC are reported, suggesting that the localization of G SH synthesis contributes to the protection against oxidative stress within hotspots of cell proliferation.
Role of Myeloperoxidase in ROS Generation and Inflammation Response on Prostate Epithelial Cells.
Thierry Roumeguere,Caroline Noyon,Pierre Van Antwerpen,Philippe Poelvoorde,Isabelle Bar,F. Abdulsater,Alexandre Rousseau,Cédric Delporte,Luc Vanhamme,Michel Vanhaeverbeek,Paul Delrée,Karim Zouaoui Boudjeltia +11 more
TL;DR: In vitro experiments showed the ability of MPO to potentiate the ROS production and inflammation on prostate epithelial cells, and further studies are mandatory to focus on the potential impact ofMPO in the development of prostatic diseases.
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