Isabel Tritschler
University of Zurich
16 Papers
7 Citations
Isabel Tritschler is an academic researcher from University of Zurich. The author has contributed to research in topics: Transforming growth factor & Glioma. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of Isabel Tritschler include Goethe University Frankfurt & University of Tübingen.
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Papers
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Christiane A. Opitz,Ulrike M. Litzenburger,Ulrike M. Litzenburger,Felix Sahm,Martina Ott,Isabel Tritschler,Saskia Trump,Theresa Schumacher,Theresa Schumacher,Leonie Jestaedt,Dieter Schrenk,Michael Weller,Manfred Jugold,Gilles J. Guillemin,Christine L. Miller,Christian Lutz,Bernhard Radlwimmer,Irina Lehmann,Andreas von Deimling,Wolfgang Wick,Michael Platten +20 more
TL;DR: Evidence is provided for a previously unidentified pathophysiological function of the AHR that is constitutively generated by human tumours via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology.
1.7K
Toll-Like Receptor Engagement Enhances the Immunosuppressive Properties of Human Bone Marrow-Derived Mesenchymal Stem Cells by Inducing Indoleamine-2,3-dioxygenase-1 via Interferon-β and Protein Kinase R
Christiane A. Opitz,Christiane A. Opitz,Ulrike M. Litzenburger,Christian Lutz,Tobias V. Lanz,Isabel Tritschler,Alexandra Köppel,Eva Tolosa,Maik Hoberg,Jan Anderl,Wilhelm K. Aicher,Michael Weller,Michael Weller,Wolfgang Wick,Wolfgang Wick,Michael Platten,Michael Platten +16 more
TL;DR: A new role for TLR is defined in MSC immunobiology, which is to augment the immunosuppressive properties of MSC in the absence of IFN‐γ rather than inducing proinflammatory immune response pathways.
321
GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas
Patrick Roth,Patrick Roth,Markus Junker,Isabel Tritschler,Michel Mittelbronn,Yvonne Dombrowski,Samuel N. Breit,Ghazaleh Tabatabai,Ghazaleh Tabatabai,Wolfgang Wick,Michael Weller,Michael Weller,Jörg Wischhusen,Jörg Wischhusen +13 more
TL;DR: It is shown that GDF-15 at endogenous levels contributes to proliferation and immune escape of malignant gliomas in an immunocompetent host.
163
Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy
Kenneth Yan,Qiulian Wu,Diana H. Yan,Christine Lee,Nasiha Rahim,Isabel Tritschler,Jennifer DeVecchio,Matthew F. Kalady,Anita B. Hjelmeland,Jeremy N. Rich +9 more
TL;DR: This study establishes CSC-derived Gremlin1 as a driving force in maintaining glioblastoma tumor proliferation and gliOBlastoma hierarchies through the modulation of endogenous prodifferentiation signals.
Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells
D Gramatzki,G Pantazis,Jens Schittenhelm,Ghazaleh Tabatabai,C Köhle,Wolfgang Wick,Wolfgang Wick,Michael Schwarz,M. Weller,M. Weller,Isabel Tritschler +10 more
TL;DR: The pathogenesis of glioma formation may involve altered AhR regulation of the TGF-β/Smad pathway, and AhR may represent a promising target for the treatment of human malignant gliomas and other diseases associated with pathological T GF-β activity.
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