Primary Salivary Gland–Type Lung Cancer: Clinicopathological Analysis of 88 Cases from China

Epithelial–myoepthelial carcinoma of the tracheobronchial tree: The prognostic role of myoepithelial cells

We report the clinical and histopathologic features of 17 patients with orf or milkers' nodule infection. The majority were male, 12 to 65 years of age, and gave a history of contact with farm animals. Most lesions affected the hands or arms, ranged in size from 1 to 3 cm, and occurred on average 3 weeks after presumed exposure. On low-power examination the epidermis showed endophytic strandlike proliferations and the dermal papillae were distended by intense edema. There was massive capillary proliferation and dilation and a dense inflammatory infiltrate. High-power examination revealed epidermal viral cytopathic changes with inclusion bodies, clumping of keratohyalin, and cytoplasmic vacuolation that had a distinctive \"spongiform\" appearance within follicular structures. We conclude that orf and milkers' nodule infection have distinctive histopathologic features, and, in contrast to some previous reports, viral changes may frequently be found.

Human orf and milkers' nodules: a clinicopathological study

Primary epithelial myoepithelial carcinoma of lung is a rare entity and is thought to arise from the submucosal bronchial glands distributed throughout the lower respiratory tract. Because of the rarity of this tumor, we describe one case of epithelial myoepithelial carcinoma arising in the bronchus intermedius and presenting as an endobronchial mass. A 57-year-old male patient presented with an incidental finding of an endobronchial mass located in the lumen of the right lower lobe bronchus and caused near total luminal occlusion of the bronchus. An endobronchial carcinoid tumor was entertained clinically. Subsequently the patient underwent an uneventful videothoracoscopic lobectomy of lower and middle lobes of the right lung. Morphologically and immunohistochemically the tumor was characterized by two cell populations with epithelial and myoepithelial cells forming duct-like structure. The final diagnosis of epithelial myoepithelial carcinoma of lung was rendered.

/pdf/primary-epithelial-myoepithelial-carcinoma-of-lung-reporting-zhh69ank16.pdf

Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. Epithelial-myoepithelial carcinoma (EMCa) is a low-grade malignant tumour. According to literature, most commonly occurs in salivary glands, particularly in parotic gland, but it can also occur in unusual locations such as breast, lachrymal gland, nose, paranasal sinus, lung, bronchus and, as in our case, trachea. There are no many documented case reports of a primary myoepithelial carcinoma in the trachea. We report a case of a 34-year-old man diagnosed with this unusual location of an epithelial-myoepithelial tumor. The tumour was removed by segmental tracheal resection and end-to-end anastomosis.

/pdf/epithelial-myoepithelial-carcinoma-of-the-trachea-a-rare-50yf69hjj3.pdf

Epithelial-myoepithelial carcinoma of the trachea—a rare entity case report

Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them, the most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of epithelial and myoepithelial elements are extraordinary infrequent, with only 11 cases collected from literature. We present the case of a 76 year-old woman with no interesting pathological history, to whom a pulmonary nodule is detected during a study of unknown origin neutropenia. An upper right lobectomy is performed. After macro and microscopic study, the diagnosis of pulmonary epithelial-myoepithelial tumour is made. It is a low malignant potential tumour with capacity to locally recur and less frequently to metastasize. Our case has the peculiarity of not being connected neither to visceral pleura nor to bronchial tree; we have not found this characteristic in any literature reviewed case. These tumours have been named in a lot of different ways, including adenomyoepithelioma, epithelial-myoepithelial tumour, epithelial-myoepithelial carcinoma or epithelial-myoepithelial tumour of uncertain malignant potential. The p27/kip-1 protein plays a fundamental role in the development of these neoplasms. As we have verified in our case, its aberrant cytoplasmic location, besides its proved oncogenic function, would favour the proliferation of stem cells, which would explain both dual phenotype with presence of myoepithelial cells without connection with the bronchial tree, and TTF-1 immunostaining in epithelial cells.

/pdf/epithelial-myoepithelial-tumour-of-the-lung-a-case-report-26gosexpj4.pdf

Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis

Se trata de un varon de 66 anos con una lesion exofitica de morfologia redondeada de 2 cm de diametro mayor, de aspecto crateriforme, de dos meses de evolucion, localizada en el dorso de la mano derecha. Como antecedente personal de interes cabe destacar que se le practico un trasplante renal hace 4 meses. Su profesion es la de cartero, y sus aficiones son pasear y coger ovejas. Su padre es labrador. Tras la exeresis de la lesion, esta recidiva al mes de la intervencion en la misma localizacion y tambien a distancia.

/pdf/lesion-cutanea-recidivante-en-paciente-trasplantado-renal-5c31m7aig2.pdf

Lesión cutánea recidivante en paciente trasplantado renal

Metanephric adenoma (MA) is a rare benign renal tumor. Radiology does not clearly differentiate between this benign lesion and renal carcinoma accurately. We report the case of a woman with history of non-Hodgkin lymphoma. CT scan showed nodules in one kidney, and radical nephrectomy was performed under the appearance of hypernephroma. Two lesions were identified, and the histopathological diagnosis was MA. No other MA has been reported in patients with non-Hodgkin lymphoma. The correct diagnosis of this tumor prevents radical nephrectomy. In the current report we describe two foci of tumor, and being MA usually solitary, its benign characteristics might be more challenging.

/pdf/bifocal-metanephric-adenoma-in-a-patient-with-non-hodgkin-500qjz2rqn.pdf

Bifocal Metanephric Adenoma in a Patient with Non-hodgkin Lymphoma

Submit Manuscript | http://medcraveonline.com of MA versus renal cell carcinoma [1]. This concept is relevant, given that initially the malignancy of MA was uncertain, although it almost always has a benign clinical course [6]. However, two cases have been reported showing malignant behavior with metastasis [6,7]. MA ranges in size, being around 30 60 mm in diameter with the largest being 200 mm [6]. This tumor is usually unifocal and unilateral, with few exceptions reported [5,6].

/pdf/bifocal-metanephric-adenoma-4h5rfusxrc.pdf

Bifocal metanephric adenoma

Francesc Felipo*, Mar Pascual*, Isabel Marquina*, Ana Fuertes*, Celia del Agua* * Servicio de Anatomia Patologica, Hospital Universitario Miguel Servet, Zaragoza ESPANA Resumen Caso clinico: Presentamos el caso de un varon de 67 anos, que presenta una tumoracion lar ingea, formada por celulas de rasgos escamosos y con presencia focal de areas de diferenciacion sebacea. El tumor metastatiza en dos ganglios linf aticos, uno de los cuales mostraba focos de diferenciacion sebacea.

/pdf/una-variante-histologica-poco-frecuente-de-carcinoma-h8jdl3srnn.pdf

Una variante histológica poco frecuente de carcinoma escamoso laríngeo

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