Isabel Lopez
Gladstone Institutes
9 Papers
10 Citations
Isabel Lopez is an academic researcher from Gladstone Institutes. The author has contributed to research in topics: Medicine & Microglia. The author has an hindex of 3, co-authored 5 publications.
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Papers
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Bettina van Lengerich,Lihong Zhan,Dan Xia,Darren K.W. Chan,David A Joy,Joshua I. Park,David Tatarakis,Meredith E. K. Calvert,Selina Hummel,Steve Lianoglou,Michelle E. Pizzo,Rachel Prorok,Elliot R. Thomsen,L. Bartos,Philipp Beumers,Anja Capell,Sonnet S. Davis,Lis de Weerd,Jason C. Dugas,Joseph N. Duque,Timothy K. Earr,Kapil Gadkar,Tina Giese,Audrey Gill,Johannes Gnörich,Connie Ha,Malavika Kannuswamy,Do Jin Kim,Sebastian T Kunte,L. Kunze,Diana Lac,Kendra J. Lechtenberg,Amy Wing-Sze Leung,Chun-Chi Liang,Isabel Lopez,Paul V. McQuade,Anuja Modi,Vanessa O Torres,Hoang Nguyen,Ida Pesämaa,Nicholas E. Propson,Marvin Reich,Yaneth Robles-Colmenares,Kai Schlepckow,L. Slemann,Hilda Solanoy,Jung H. Suh,Robert G. Thorne,Chandler Vieira,Karin Wind-Mark,Ken Xiong,Y. Joy Yu Zuchero,Dolo Diaz,Mark S. Dennis,Fen Huang,Kimberly Scearce-Levie,Ryan J. Watts,Christian Haass,Joseph W. Lewcock,Gilbert Di Paolo,Matthias Brendel,Pascal E. Sanchez,Kathryn M. Monroe +62 more
TL;DR: A high affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle (ATV), was used to facilitate blood-brain barrier transcytosis as mentioned in this paper .
Tau Reduction Prevents Key Features of Autism in Mouse Models
Chao Tai,Che-Wei Chang,Gui-Qiu Yu,Isabel Lopez,Xinxing Yu,Xin Wang,Weikun Guo,Lennart Mucke,Lennart Mucke +8 more
TL;DR: It is shown that genetically reducing the protein tau prevents behavioral signs of autism in two mouse models simulating distinct causes of this condition and suggests an enabling role of tau in the pathogenesis of autism.
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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
Annie Arguello,René Meisner,Elliot R. Thomsen,Hoang N. Nguyen,Ritesh Ravi,Jeffrey Simms,Iris Lo,Jessica Speckart,Julia Holtzman,Thomas M. Gill,Darren Chan,Yuhsiang Cheng,Chi-Lu Chiu,Jason C. Dugas,Meng Fang,Isabel Lopez,Hilda Solanoy,Buyankhishig Tsogtbaatar,Yuda Zhu,Akhil Bhalla,Kirk R. Henne,Anastasia G. Henry,Anthony Delucchi,Simona Costanzo,Jeffrey M. Harris,Dolores Diaz,Kimberly Scearce-Levie,Pascal E. Sanchez +27 more
TL;DR: In this article, an IDS transport vehicle (ETV:IDS) was developed to bind to the transferrin receptor, which facilitates receptor-mediated transcytosis of IDS across the blood-brain barrier and improves its distribution into the brain.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.