Isabel Espadas
Spanish National Research Council
11 Papers
147 Citations
Isabel Espadas is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Hippocampal formation & Long-term potentiation. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Isabel Espadas include Carlos III Health Institute & Cajal Institute.
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Papers
Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null, Drd1a−/− Mice and in Hippocampal siRNA Silenced Drd1a Mice
Oskar Ortiz,José M. Delgado-García,Isabel Espadas,Amine Bahi,Ramon Trullas,Jean-Luc Dreyer,Agnès Gruart,Rosario Moratalla +7 more
TL;DR: A functional relationship between acquisition of associative learning, increase in synaptic strength at the CA3–CA1 synapse, and Egr1 induction in the hippocampus is revealed by demonstrating that all three are dramatically impaired when D1R is eliminated or reduced.
N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease
Patricia García-Sanz,Lorena Orgaz,Guillermo Bueno-Gil,Isabel Espadas,Eva Rodríguez-Traver,Jaime Kulisevsky,Antonia Gutierrez,Jose Carlos Davila,Rosa A. González-Polo,José M. Fuentes,Pablo Mir,Carlos Vicario,Rosario Moratalla +12 more
TL;DR: The aim of this study was to explore the impact of the N370S‐GBA1 mutation on cellular homeostasis and vulnerability in a patient‐specific cellular model of PD.
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Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
TL;DR: It is demonstrated that targeting the NO/cGMP signaling pathway reduces dyskinetic behaviors and molecular markers, but only the 7-NI treatment preserved the antiparkinsonian effect of l-DOPA, indicating that NOS inhibitors represent a potential therapy to reduce LID.
69
Involvement of Cannabinoid CB1 Receptor in Associative Learning and in Hippocampal CA3–CA1 Synaptic Plasticity
Noelia Madroñal,Agnès Gruart,Olga Valverde,Isabel Espadas,Rosario Moratalla,Rosario Moratalla,José M. Delgado-García +6 more
TL;DR: The contribution of CB1 receptors to the activity-dependent changes induced at the hippocampal CA3-CA1 synapse by associative learning and following experimentally evoked long-term potentiation (LTP) is studied.
34
L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: insights into regulation and function
Isabel Espadas,Sanja Darmopil,Sanja Darmopil,Eva Vergaño-Vera,Eva Vergaño-Vera,Oskar Ortiz,Oskar Ortiz,Idaira Oliva,Carlos Vicario-Abejón,Carlos Vicario-Abejón,Eduardo D. Martín,Rosario Moratalla,Rosario Moratalla +12 more
TL;DR: The results suggest that the presence of TH-ir neurons in the striatum may underlie the long-duration response to L-DOPA following withdrawal, and may be beneficial for maintaining motor function in the early stages of Parkinson's disease.