Isabel Chillón
European Bioinformatics Institute
13 Papers
135 Citations
Isabel Chillón is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: RNA splicing & Group II intron. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Isabel Chillón include Yale University & Howard Hughes Medical Institute.
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Papers
HOTAIR Forms an Intricate and Modular Secondary Structure
Srinivas Somarowthu,Michal Legiewicz,Isabel Chillón,Marco Marcia,Fei Liu,Anna Marie Pyle,Anna Marie Pyle +6 more
TL;DR: The HOTAIR structure reveals a degree of structural organization comparable to well-folded RNAs, like the group II intron, rRNA, or lncRNA steroid receptor activator, and is composed of four independently folding modules, two of which correspond to predicted protein-binding domains.
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Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing
Jacopo Manigrasso,Isabel Chillón,Vito Genna,Pietro Vidossich,Srinivas Somarowthu,Anna Marie Pyle,Marco De Vivo,Marco Marcia +7 more
TL;DR: These insights into the mechanism of group II intron splicing parallels functional data on the spliceosome, thus reinforcing the notion that these evolutionarily-related molecular machines share the same enzymatic strategy.
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.
Tina Uroda,Eleni Anastasakou,Annalisa Rossi,Jean-Marie Teulon,Jean-Luc Pellequer,Paolo Annibale,Ombeline Pessey,Alberto Inga,Isabel Chillón,Marco Marcia +9 more
TL;DR: It is found that, in an evolutionary conserved region of MEG3, two distal motifs interact by base complementarity to form alternative, mutually exclusive pseudoknot structures (“kissing loops”).
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Native Purification and Analysis of Long RNAs.
Isabel Chillón,Marco Marcia,Michal Legiewicz,Fei Liu,Srinivas Somarowthu,Anna Marie Pyle,Anna Marie Pyle +6 more
TL;DR: How to study lnc RNA global compaction in the presence of divalent ions at equilibrium using sedimentation velocity analytical ultracentrifugation and analytical size-exclusion chromatography as well as how to use these uniform RNA species to determine robust lncRNA secondary structure maps by chemical probing techniques like selective 2'-hydroxyl acylation analyzed by primer extension and dimethyl sulfate probing.