Iryna Voytyuk
Katholieke Universiteit Leuven
12 Papers
52 Citations
Iryna Voytyuk is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Biology & Amyloid precursor protein. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Iryna Voytyuk include University of Cambridge & Allen Institute for Brain Science.
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Papers
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Carlo Sala Frigerio,Carlo Sala Frigerio,Leen Wolfs,Nicola Fattorelli,Nicola Thrupp,Iryna Voytyuk,Inga Schmidt,Renzo Mancuso,Wei Ting Chen,Maya E. Woodbury,Gyan Srivastava,Thomas Möller,Eloise Hudry,Sudeshna Das,Takaomi C. Saido,Eric Karran,Bradley T. Hyman,V. Hugh Perry,V. Hugh Perry,Mark Fiers,Bart De Strooper,Bart De Strooper +21 more
TL;DR: Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female AppNL-G-F mice over time demonstrate that progressive amyloid-b accumulation accelerates two main activated microglia states that are also present during normal aging.
707
The β-Secretase BACE1 in Alzheimer's Disease.
Harald Hampel,Robert Vassar,Bart De Strooper,Bart De Strooper,Bart De Strooper,John Hardy,Michael Willem,Neeraj Kumar Singh,John Zhou,Riqiang Yan,Eugeen Vanmechelen,Ann De Vos,Robert Nisticò,Massimo Corbo,Bruno P. Imbimbo,Johannes Streffer,Iryna Voytyuk,Iryna Voytyuk,Iryna Voytyuk,Maarten Timmers,Maarten Timmers,Amir Abbas Tahami Monfared,Amir Abbas Tahami Monfared,Michael C. Irizarry,Bruce Albala,Akihiko Koyama,Naoto Watanabe,Teiji Kimura,Lisa Yarenis,Simone Lista,Simone Lista,Lynn D. Kramer,Andrea Vergallo +32 more
TL;DR: BACE1 concentrations and rates of activity are increased in AD brains and body fluids, thereby supporting the hypothesis that BACE1 plays a critical role in AD pathophysiology, and is a prime drug target for slowing down Aβ production in early AD.
499
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.
Sebastiaan De Schepper,Simon Verheijden,Javier Aguilera-Lizarraga,Maria Francesca Viola,Werend Boesmans,Nathalie Stakenborg,Iryna Voytyuk,Inga Schmidt,Bram Boeckx,Isabelle Dierckx de Casterlé,Veerle Baekelandt,Erika Gonzalez Dominguez,Matthias Mack,Inge Depoortere,Bart De Strooper,Bart De Strooper,Ben Sprangers,Uwe Himmelreich,Stefaan J. Soenen,Martin Guilliams,Pieter Vanden Berghe,Elizabeth A. V. Jones,Diether Lambrechts,Guy E. Boeckxstaens +23 more
TL;DR: A self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood is identified and its strategic role in gut homeostasis and intestinal physiology is demonstrated.
463
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Martina Pigoni,Martina Pigoni,Johanna Wanngren,Johanna Wanngren,Peer-Hendrik Kuhn,Kathryn M. Munro,Jenny M. Gunnersen,Jenny M. Gunnersen,Hiroshi Takeshima,Regina Feederle,Iryna Voytyuk,Bart De Strooper,Bart De Strooper,Mikail D. Levasseur,Brian Joel Hrupka,Stephan A. Müller,Stephan A. Müller,Stefan F. Lichtenthaler +17 more
TL;DR: This study demonstrates that SEZ 6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEz6L levels in CSF are suitable markers to monitor Bace1 inhibition in mice.