Irving L. Weissman
Stanford University
1170 Papers
18.9K Citations
Irving L. Weissman is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 201, co-authored 1141 publications. Previous affiliations of Irving L. Weissman include Eli Lilly and Company & Memorial Sloan Kettering Cancer Center.
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Papers
•Journal Article
Chimeras in colonial invertebrates: a synergistic symbiosis or somatic- and germ-cell parasitism?
TL;DR: It is suggested that chimerism in invertebrates is characterized by somatic and germ cell parasitism rather than synergistic symbiosis and other benefits, and involves an array of competitive interactions between the two partners.
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Hepatic regeneration from hematopoietic stem cells
Eric Lagasse,Irving L. Weissman +1 more
TL;DR: The unexpected observations that hematopoietic stem cells can contribute to the hepatocyte lineage in humans and in rodent models of liver disease and regeneration are discussed.
85
Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes
Michael E. P. Murphy,John Moult,R. C. Bleackley,Howard K. Gershenfeld,Irving L. Weissman,Michael N.G. James +5 more
TL;DR: Comparative molecular model building using the known three‐dimensional structures and the derived amino acid sequences of the lymphocyte enzymes has been provided useful information, especially in predicting the conformations of the substrate binding sites.
84
Proliferation and differentiation of highly enriched mouse hematopoietic stem cells and progenitor cells in response to defined growth factors.
TL;DR: The finding that IL-3 can stimulate at least two distinct clonogenic early progenitor cells in normal bone marrow indicates that multipotent and restricted progenitors can be separated on the basis of the expression of the cell surface antigen Thy-1.
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Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain.
TL;DR: The results suggest that alpha 4 beta 7 can be expressed in a constitutively active state, the beta 7 cytoplasmic domain regulates the avidity of alpha 4beta 7, and 38C13 cell lines expressing wild-type and truncated beta 7 subunits define three stable activation states of alpha 3 beta 7: inactive, partially active, and fully active receptors.
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