Irun R. Cohen
Weizmann Institute of Science
626 Papers
11.4K Citations
Irun R. Cohen is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 93, co-authored 626 publications. Previous affiliations of Irun R. Cohen include Brigham and Women's Hospital & University of Düsseldorf.
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Papers
•Journal Article
IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2.
Felix Mor,Irun R. Cohen +1 more
TL;DR: In this article, the authors studied the effect of IL-2 on T lymphocytes from the thymus, and found that IL2 can prevent T cells from entering apoptosis induced by gamma-irradiation, mitomycin C, or dexamethasone.
Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion
Ehud Hauben,Oleg Butovsky,Uri Nevo,Eti Yoles,Gila Moalem,Eugenia Agranov,Felix Mor,Raya Leibowitz-Amit,Evgenie Pevsner,Solange Akselrod,Michal Neeman,Irun R. Cohen,Michal Schwartz +12 more
TL;DR: The results suggest that T cell-mediated immune activity, achieved by either adoptive transfer or active immunization, enhances recovery from spinal cord injury by conferring effective neuroprotection.
Heat Shock Protein 60 Activates B Cells via the TLR4-MyD88 Pathway
Michal Cohen-Sfady,Gabriel Nussbaum,Gabriel Nussbaum,Meirav Pevsner-Fischer,Felix Mor,Pnina Carmi,Alexandra Zanin-Zhorov,Ofer Lider,Irun R. Cohen +8 more
TL;DR: It is found that human HSP60 (but not the Escherichia coli GroEL or the Mycobacterial HSP65 molecules) induced naive mouse B cells to proliferate and to secrete IL-10 and IL-6.
Spontaneous remission of autoimmune encephalomyelitis is inhibited by splenectomy, thymectomy or ageing
TL;DR: It is reported here that chronic progressive EAE with marked myelin lesions can be induced by a single injection of BP in complete Freund's adjuvant in intact 13-month old rats, or in 4- month old rats provided they have been splenectomized.
Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin.
TL;DR: Mice immunized with insulin developed antibodies to both insulin and the insulin receptor, resulting in antibodies to the hormone receptor, which indicates that immunization against a hormone may activate spontaneously an idiotype-anti-idiotype network.