Irmgard Merfort
University of Freiburg
209 Papers
1.6K Citations
Irmgard Merfort is an academic researcher from University of Freiburg. The author has contributed to research in topics: Arnica montana & Chemistry. The author has an hindex of 48, co-authored 207 publications. Previous affiliations of Irmgard Merfort include University of Costa Rica & University of Düsseldorf.
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Papers
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin.
TL;DR: In vivo and in vivo, luteolin reduced increased vascular permeability and was effective in animal models of inflammation after parenteral and oral application, indicating that it has the potential to protect from diseases associated with inflammatory processes such as cardiovascular disease.
Anti-carcinogenic Effects of the Flavonoid Luteolin
TL;DR: Luteolin displays specific anti-inflammatory and anti-carcinogenic effects, which can only partly be explained by its anti-oxidant and free radical scavenging capacities.
Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.
TL;DR: The scratch assay in the present form can be used as a promising scientific approach and platform to differentiate between plant extracts known for their wound healing and their anti-inflammatory properties.
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Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
Peter Rüngeler,Victor Castro,Gerardo A. Mora,Nezhun Gören,Walter Vichnewski,Heike L. Pahl,Irmgard Merfort,Thomas J. Schmidt +7 more
TL;DR: A molecular mechanism of action is proposed, which is able to explain the p65 selectivity of the SLs and the observed correlation of high activity with alkylant bifunctionality.
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