Irit Rappley
Scripps Research Institute
4 Papers
Irit Rappley is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Transthyretin & Chemistry. The author has an hindex of 2, co-authored 2 publications.
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Papers
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
Sravan C. Penchala,Stephen Connelly,Yu Wang,Miki S. Park,Lei Zhao,Aleksandra Baranczak,Irit Rappley,Hannes Vogel,Michaela Liedtke,Ronald M. Witteles,Evan T. Powers,Natàlia Reixach,William K. Chan,Ian A. Wilson,Jeffery W. Kelly,Isabella A. Graef,Mamoun M. Alhamadsheh +16 more
TL;DR: The development of AG10 is reported, a potent and selective kinetic stabilizer of TTR, which prevents dissociation of V122I-TTR in serum samples obtained from patients with familial amyloid cardiomyopathy and makes it a very promising candidate to treat TTR amyloids cardiopathy.
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Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange
Irit Rappley,Cecília Monteiro,Marta Novais,Aleksandra Baranczak,Gregory M. Solis,R. Luke Wiseman,Stephen Helmke,Mathew S. Maurer,Teresa Coelho,Evan T. Powers,Jeffery W. Kelly +10 more
TL;DR: Subunit exchange was used to quantify the stabilization of WT TTR from senile systemic amyloidosis patients currently being treated with tafamidis (20 mg orally, once daily), and TTR kinetic stability correlated with the tAFamidis plasma concentration.
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Aging, Parkinson’s Disease, and Models: What Are the Challenges?
Ilaria Bellantuono,Heather Mortiboys,Emily M. Rocha,Manish Chamoli,Shankar J. Chinta,Julie K. Andersen,Ruby Wallis,Erwan Bezard,Matt Goldberg,Timothy Greenamyre,Warren Hirst,We-Li Kuan,Deniz Kirik,Laura J. Niedernhofer,Irit Rappley,K. Padmanabhan,Louis-Eric Trudeau,Maria Grazia Spillantini,Simon Scott,Lorenz Studer +19 more
- 04 Aug 2023
TL;DR: It is proposed that an investment in time and resources, together with the coordination and sharing of resources, knowledge, and data, is required to accelerate progress in understanding the role of biological aging in PD development and improve the reliability of models to test interventions.
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Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets
Jenny A. Rudnick,Kiran S. Nadella,Shane Rowley,Ethan Gardner,Shadi Swaidani,Aimee Iberg,Daria Beshnova,Aurora Blucher,Rebecca Sarto Basso,Malini Rajan,Ashraf Abbas Saeed,John H. Ansede,Pouya Hadipour,Kevin W. Jessing,Janet L. Paulsen,Paul Rearden,Vamshi K. Manda,Sashi G. Kasimsetty,Harish Shankaran,Meenakshy Iyer,Ashish Bhandari,Irit Rappley,Laura Schaevitz,Imran Haque,Hayley J. Donnella,Michael F. Cuccarese,Marie Evangelista +26 more
TL;DR: Rudnick et al. as mentioned in this paper combined high-content microscopy with arrayed CRISPR genome editing techniques and machine learning (ML) to build a rigorously controlled dataset enabling exploration of biology and chemistry at scale.
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