Iris Rohner
University of Marburg
6 Papers
Iris Rohner is an academic researcher from University of Marburg. The author has contributed to research in topics: Histone & Medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Bastian Stielow,Yuqiao Zhou,Yinghua Cao,Clara Simon,Hans-Martin Pogoda,Junyi Jiang,Yanpeng Ren,Sabrina K. Phanor,Iris Rohner,Andrea Nist,Thorsten Stiewe,Matthias Hammerschmidt,Yang Shi,Yang Shi,Martha L. Bulyk,Zhanxin Wang,Robert Liefke +16 more
TL;DR: In this article, the authors identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CpG-binding protein, which has an atypical winged-helix domain that directly recognizes unmethylation CpGs-containing DNA via simultaneous interactions with both the major and minor groove.
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The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Weber,Yu Jia,Bastian Stielow,Stephen S. Gisselbrecht,Yinghua Cao,Yi Ren,Iris Rohner,Jessica King,Elisabeth Rothman,S. Fischer,Clara Simon,Ignasi Forné,Andrea Nist,Thorsten Stiewe,Martha L. Bulyk,Zhanxin Wang,Robert Liefke +16 more
TL;DR: In this paper , the winged helix (WH) domain at the very N-terminus of KAT6A specifically interacts with unmethylated CpG motifs.
The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells
Clara Simon,Bastian Stielow,Andrea Nist,Iris Rohner,Lisa Weber,Merle Geller,Sabrina Fischer,Thorsten Stiewe,Robert Liefke +8 more
TL;DR: It is demonstrated that the deletion of SAMD1 in HepG2 cells leads to aberrant gene regulation and to a gene signature linked to a better prognosis, which suggests that S AMD1 is involved in establishing a pro-proliferative setting in hepatocellular carcinoma cells.
SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma
Clara Simon,Inka D. Brunke,Bastian Stielow,Ignasi Forné,A. Steitz,Merle Geller,Iris Rohner,Lisa Weber,S. Fischer,Lea Marie Jeude,Andrea Nist,Thorsten Stiewe,Magdalena Huber,Malte Buchholz,Robert Liefke +14 more
TL;DR: New insights are provided into the regulation of EMT-related genes in PDAC, shedding light on the intricate role of SAMD1 and its interplay with FBXO11 in this cancer type.
Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin
Merle Geller,Yinghua Cao,Clara Simon,Bastian Stielow,Jingfei Xu,Pengshuai Wei,Andrea Nist,Iris Rohner,Lea Marie Jeude,Theresa Huber,Thorsten Stiewe,Zhanxin Wang,Robert Liefke +12 more