Iris Moll
German Cancer Research Center
28 Papers
66 Citations
Iris Moll is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Notch signaling pathway & Melanoma. The author has an hindex of 15, co-authored 22 publications. Previous affiliations of Iris Moll include University of Duisburg-Essen.
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Papers
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn,Adina Figl,P. Sivaramakrishna Rachakonda,Christine Fischer,Antje Sucker,Andreas Gast,Stephanie Kadel,Iris Moll,Eduardo Nagore,Kari Hemminki,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +12 more
TL;DR: A melanoma-prone family through linkage analysis and high-throughput sequencing was investigated and a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomersase, caused up to twofold increase in transcription.
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Endothelial Notch1 Activity Facilitates Metastasis
Elfriede Wieland,Juan Rodriguez-Vita,Sven S. Liebler,Sven S. Liebler,Carolin Mogler,Iris Moll,Stefanie E. Herberich,Stefanie E. Herberich,Elisa Espinet,Esther Herpel,Amitai Menuchin,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Christoffer Gebhardt,Hermann Brenner,Andreas Trumpp,Christian W. Siebel,Markus Hecker,Jochen Utikal,David Sprinzak,Andreas Fischer,Andreas Fischer +22 more
TL;DR: Sustained vascular Notch signaling facilitates metastasis by generating a senescent, pro-inflammatory endothelium and treatment with Notch1 or VCAM1-blocking antibodies prevented Notch-driven metastasis, and genetic ablation of EC notch signaling inhibited peritoneal neutrophil infiltration in an ovarian carcinoma mouse model.
289
Differential Clinical Significance of Individual NKG2D Ligands in Melanoma: Soluble ULBP2 as an Indicator of Poor Prognosis Superior to S100B
Annette Paschen,Antje Sucker,Bettina Hill,Iris Moll,Marc Zapatka,Xuan Duc Nguyen,Geok Choo Sim,Isabelle Gutmann,Jessica C. Hassel,Jürgen C. Becker,Alexander Steinle,Dirk Schadendorf,Selma Ugurel +12 more
TL;DR: Only sULBP2 is an independent predictor of prognosis, the significance of which is superior to the well-established and widely used melanoma serum marker S100B.
193
Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.
Markus Jabs,Adam J. Rose,Adam J. Rose,Lorenz H. Lehmann,Jacqueline Taylor,Iris Moll,Tjeerd P. Sijmonsma,Stefanie E. Herberich,Sven W. Sauer,Gernot Poschet,Giuseppina Federico,Carolin Mogler,Eva-Maria Weis,Hellmut G. Augustin,Minhong Yan,Norbert Gretz,Roland M. Schmid,Ralf H. Adams,Hermann-Joseph Gröne,Rüdiger Hell,Jürgen G. Okun,Johannes Backs,Peter P. Nawroth,Stephan Herzig,Andreas Fischer +24 more
TL;DR: Notch signaling is identified as a novel regulator of fatty acid transport across the endothelium and as an essential repressor of angiogenesis in the adult heart, implying that the endothelialium controls cardiomyocyte metabolism and function.
136
TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma
Klaus G. Griewank,Rajmohan Murali,Bastian Schilling,Tobias Schimming,Inga Möller,Iris Moll,Marion Schwamborn,Antje Sucker,Lisa Zimmer,Dirk Schadendorf,Uwe Hillen +10 more
TL;DR: It is shown that TERT promoter mutations with UV-signatures are frequent in non-melanoma skin cancer, being present in around 50% of basal and squamous cell carcinomas and suggests that increased expression of telomerase plays an important role in the pathogenesis of these tumors.