Iris Eke
Stanford University
56 Papers
370 Citations
Iris Eke is an academic researcher from Stanford University. The author has contributed to research in topics: Focal adhesion & Integrin. The author has an hindex of 23, co-authored 53 publications. Previous affiliations of Iris Eke include German Cancer Research Center & Helmholtz-Zentrum Dresden-Rossendorf.
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Papers
Focal adhesion signaling and therapy resistance in cancer
Iris Eke,Nils Cordes +1 more
TL;DR: Insight is given into the role of integrins in carcinogenesis, tumor progression and metastasis and literature and data about the function of focal adhesion molecules includingIntegrins, integrin-associated proteins and growth factor receptors in tumor cell resistance to radio- and chemotherapy will be elucidated and discussed.
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PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α
Iris Eke,Ulrike Koch,Stephanie Hehlgans,Veit Sandfort,Fabio Stanchi,Daniel Zips,Michael Baumann,Anna Shevchenko,Christian Pilarsky,Michael Haase,Gustavo B. Baretton,Véronique Calleja,Banafshé Larijani,Reinhard Fässler,Nils Cordes +14 more
TL;DR: The data suggest that targeting signaling molecules such as PINCH1 that function downstream of focal adhesions (the complexes that mediate tumor cell adhesion to ECM) may overcome radio- and chemoresistance, providing new therapeutic approaches for cancer.
The Future of Radiobiology.
David G. Kirsch,Max Diehn,Aparna H. Kesarwala,Amit Maity,Meredith A. Morgan,Julie K. Schwarz,Robert G. Bristow,Sandra Demaria,Iris Eke,Robert J. Griffin,Daphne A. Haas-Kogan,Geoff S. Higgins,Alec C. Kimmelman,Randall J. Kimple,Isabelle M.A. Lombaert,Li Ma,Brian Marples,Frank Pajonk,Catherine C. Park,Dörthe Schaue,Eric J. Bernhard +20 more
TL;DR: The discussions of current radiation oncology research approaches and areas of scientific focus considered important for rapid progress in radiation sciences and the continued contribution of radiobiology to radiation onCology and the broader biomedical research community are reviewed.
Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.
Deborah Citrin,Pataje G. S. Prasanna,Amanda J. Walker,Michael L. Freeman,Iris Eke,Mary Helen Barcellos-Hoff,Molykutty J. Arankalayil,Eric P. Cohen,Ruth C. Wilkins,Mansoor M. Ahmed,Mitchell S. Anscher,Benjamin Movsas,Jeffrey C. Buchsbaum,Marc S. Mendonca,Thomas A. Wynn,C. Norman Coleman +15 more
TL;DR: It was felt that optimally designed preclinical models are needed to better study biomarkers that predict for development of RIF, as well as to understand when effective therapies need to be initiated in relationship to manifestation of injury.
Targeting of beta 1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells
Ellen Dickreuter,Ellen Dickreuter,Iris Eke,Iris Eke,Mechthild Krause,Kerstin Borgmann,van Marcel Vugt,Nils Cordes +7 more
TL;DR: Combined targeting of β1 integrin and PARP as promising approach for radiosensitization of HNSCC and a regulatory role forβ1 integrins in the repair of radiogenic DNA damage via classical NHEJ is highlighted.
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