Iris Böselt
Leipzig University
5 Papers
11 Citations
Iris Böselt is an academic researcher from Leipzig University. The author has contributed to research in topics: Receptor & Chemokine receptor. The author has an hindex of 5, co-authored 5 publications.
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Papers
Evolution of GPCR: change and continuity.
Rainer Strotmann,Kristin Schröck,Iris Böselt,Claudia Stäubert,Andreas Russ,Torsten Schöneberg +5 more
TL;DR: The main conclusions from studies at different levels of evolution can be summarized: at the levels of sequence comparisons between species from different families, orders and classes, and at the level of populations within a species.
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Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates
Claudia Stäubert,Iris Böselt,Jens Bohnekamp,Holger Römpler,Wolfgang Enard,Torsten Schöneberg +5 more
TL;DR: It is suggested that the previously identified volatile amine TAAR3–5 agonists reflect the high agonist promiscuity of TAAR, and that the ligands driving purifying selection of these TAAR in mouse and other mammals still await discovery.
Involvement of the V2 Vasopressin Receptor in Adaptation to Limited Water Supply
Iris Böselt,Holger Römpler,Holger Römpler,Thomas Hermsdorf,Doreen Thor,Wibke Busch,Angela Schulz,Torsten Schöneberg +7 more
TL;DR: Comparison of over 80 mammalian V2 vasopressin receptor (V2R) orthologs revealed high structural and functional conservation of this key component involved in renal water reabsorption, indicating an essential role of V2R activity for survival even of those species with unlimited access to water.
Involvement of the chemokine-like receptor GPR33 in innate immunity
Jens Bohnekamp,Iris Böselt,Anja Saalbach,Anke Tönjes,Peter Kovacs,Heike Biebermann,HM Manvelyan,Tobias Polte,Daniela Gasperikova,Sodnomtsogt Lkhagvasuren,Leslie J. Baier,Michael Stumvoll,Holger Römpler,Torsten Schöneberg +13 more
TL;DR: An important role of GPR33 function in innate immunity which became dispensable during human evolution most likely due to past or balancing selection is indicated.
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Functional characterization of novel loss-of-function mutations in the vasopressin type 2 receptor gene causing nephrogenic diabetes insipidus
Iris Böselt,Despoina Tramma,Serafia Kalamitsou,Thomas Niemeyer,Päivi Nykänen,Klaus-Jürgen Gräf,Heiko Krude,Karen Sabrina Marenzi,Stefania Di Candia,Torsten Schöneberg,Angela Schulz +10 more
TL;DR: In-depth in vitro characterization of novel AVPR2 mutants by a combination of functional and immunological techniques provided further insight into molecular mechanisms causing receptor dysfunction and proof that these mutations are responsible for causing NDI in the affected subjects.