Iris Barshack
Sheba Medical Center
282 Papers
1.3K Citations
Iris Barshack is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 49, co-authored 257 publications. Previous affiliations of Iris Barshack include Bar-Ilan University & Tel Aviv University.
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Papers
The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Deborah Nejman,Ilana Livyatan,Garold Fuks,Nancy Gavert,Yaara Zwang,Leore T. Geller,Aviva Rotter-Maskowitz,Roi Weiser,Roi Weiser,Giuseppe Mallel,Elinor Gigi,Arnon Meltser,Gavin M. Douglas,Iris Kamer,Vancheswaran Gopalakrishnan,Tali Dadosh,Smadar Levin-Zaidman,Sofia Avnet,Tehila Atlan,Zachary A. Cooper,Reetakshi Arora,Alexandria P. Cogdill,Abdul Wadud Khan,Gabriel Ologun,Yuval Bussi,Adina Weinberger,Maya Lotan-Pompan,Ofra Golani,Gili Perry,Merav Rokah,Keren Bahar-Shany,Elisa A. Rozeman,Christian U. Blank,Anat Ronai,Ron Shaoul,Amnon Amit,Amnon Amit,Tatiana Dorfman,Ran Kremer,Zvi R. Cohen,Zvi R. Cohen,Sagi Harnof,Sagi Harnof,Tali Siegal,Einav Yehuda-Shnaidman,Einav Nili Gal-Yam,Hagit Shapira,Nicola Baldini,Morgan G. I. Langille,Alon Ben-Nun,Alon Ben-Nun,Bella Kaufman,Bella Kaufman,Aviram Nissan,Talia Golan,Talia Golan,Maya Dadiani,Keren Levanon,Keren Levanon,Jair Bar,Jair Bar,Shlomit Yust-Katz,Shlomit Yust-Katz,Iris Barshack,Iris Barshack,Daniel S. Peeper,Dan J. Raz,Eran Segal,Jennifer A. Wargo,Judith Sandbank,Noam Shental,Ravid Straussman +71 more
TL;DR: A comprehensive analysis of the tumor microbiome was undertaken, studying 1526 tumors and their adjacent normal tissues across seven cancer types, finding that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome.
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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Leore T. Geller,Michal Barzily-Rokni,Tal Danino,Oliver Jonas,Oliver Jonas,Noam Shental,Deborah Nejman,Nancy Gavert,Yaara Zwang,Zachary A. Cooper,Kevin Shee,Christoph A. Thaiss,Alexandre Reuben,Jonathan Livny,Roi Avraham,Dennie T. Frederick,Matteo Ligorio,Kelly Chatman,Stephen Johnston,Carrie M. Mosher,Alexander Brandis,Garold Fuks,Candice Gurbatri,Vancheswaran Gopalakrishnan,Michael P. Kim,Mark W. Hurd,Matthew H.G. Katz,Jason B. Fleming,Anirban Maitra,David Smith,Matthew Skalak,Jeffrey Bu,Monia Michaud,Sunia A. Trauger,Iris Barshack,Iris Barshack,Talia Golan,Talia Golan,Judith Sandbank,Keith T. Flaherty,Anna Mandinova,Anna Mandinova,Wendy S. Garrett,Wendy S. Garrett,Sarah P. Thayer,Cristina R. Ferrone,Curtis Huttenhower,Curtis Huttenhower,Sangeeta N. Bhatia,Dirk Gevers,Jennifer A. Wargo,Todd R. Golub,Todd R. Golub,Ravid Straussman +53 more
TL;DR: By studying colon cancer models, it is found that bacteria can metabolize the chemotherapeutic drug gemcitabine into its inactive form, 2′,2′-difluorodeoxyuridine, seen primarily in Gammaproteobacteria.
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Erez N. Baruch,Erez N. Baruch,Ilan Youngster,Guy Ben-Betzalel,Rona Ortenberg,Adi Lahat,Lior H. Katz,Katerina Adler,Daniela Dick-Necula,Stephen P. Raskin,Stephen P. Raskin,Naamah Bloch,Daniil Rotin,Liat Anafi,Camila Avivi,Jenny Melnichenko,Yael Steinberg-Silman,Ronac Mamtani,Hagit Harati,Nethanel Asher,Ronnie Shapira-Frommer,Tal Brosh-Nissimov,Yael Eshet,Yael Eshet,Shira Ben-Simon,Oren Ziv,Abdul Wadud Khan,Moran Amit,Nadim J. Ajami,Iris Barshack,Iris Barshack,Jacob Schachter,Jacob Schachter,Jennifer A. Wargo,Omry Koren,Gal Markel,Gal Markel,Ben Boursi,Ben Boursi,Ben Boursi +39 more
TL;DR: Treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment, which have implications for modulating the gut microbiota in cancer treatment.
1K
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.
Sarah Ferber,Amir Halkin,Hofit Cohen,Idit Ber,Idit Ber,Yulia Einav,Iris Goldberg,Iris Barshack,Rhona Seijffers,Rhona Seijffers,Juri Kopolovic,Juri Kopolovic,Nurit Kaiser,Avraham Karasik,Avraham Karasik +14 more
TL;DR: The capacity of PDX-1 to reprogram extrapancreatic tissue towards a β-cell phenotype, may provide a valuable approach for generating ‘self’ surrogate β cells, suitable for replacing impaired islet-cell function in diabetics.
825
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
Lian Narunsky-Haziza,Gregory D. Sepich-Poore,Ilana Livyatan,Omer Asraf,Cameron Martino,Deborah Nejman,Nancy Gavert,Jason E. Stajich,Guy Amit,Antonio Gonzalez,Stephen Wandro,Gili Perry,Ruthie Ariel,Arnon Meltser,Justin P. Shaffer,Qiyun Zhu,Nora Balint-Lahat,Iris Barshack,Maya Dadiani,Einav Nili Gal-Yam,Sandip Pravin Patel,Amir Bashan,Austin D. Swafford,Yitzhak Pilpel,Rob Knight,Ravid Straussman +25 more
TL;DR: In this article , the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 cancer types in four independent cohorts was comprehensively characterized, with fungal DNA and cells at low abundances across many major human cancers.
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