Iris Baars
Otto-von-Guericke University Magdeburg
4 Papers
Iris Baars is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Intracellular parasite & Leishmania major. The author has an hindex of 1, co-authored 2 publications.
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Papers
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.
Sandrina Heyde,Lars Philipsen,Pauline Formaglio,Yan Fu,Iris Baars,Guido Höbbel,Corinna L. Kleinholz,Elena A. Seiß,Juliane Stettin,Patricia Gintschel,Anne Dudeck,Philippe Bousso,Burkhart Schraven,Andreas Müller +13 more
TL;DR: It is proposed that among these cells, CD11c-expressing monocytes are most permissive for pathogen proliferation, and thus mainly fuel the cycle of intracellular proliferation and cell-to-cell transfer during the acute infection.
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate.
Iris Baars,Yan Fu,Tobias J. Franz,Juliane Mohr,Patricia Gintschel,Burkhart Schraven,Sascha Kahlfuss,Ger van Zandbergen,Andreas Müller +8 more
TL;DR: In this article , the authors used 2-photon microscopy of caspase-3 activation in the Leishmania major (L. major)-infected live skin to show increased apoptosis in cells infected by the parasite, and showed that transfer of the parasite to new host cells occurred directly without a detectable extracellular state, and was associated with concomitant uptake of cellular material from the original host cell.
Investigating pyroptosis as a mechanism of L. major cell-to-cell spread in the human BLaER1 infection model.
Kerren Volkmar,Moritz Jaedtka,Iris Baars,Bianca Walber,Marie-Sophie Philipp,Katrin Bagola,Andreas Müller,Holger Heine,Ger van Zandbergen +8 more
TL;DR: It is demonstrated that impairment of the pyroPTosis pathway leads to lower rates of parasite spread to new host cells, thus, implicating pyroptotic cell death as a possible exit mechanism of L. major in pro-inflammatory microenvironments.
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Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection
Iris Baars,Juliane Lokau,Juliane Lokau,Ina Sauerland,Andreas Müller,Christoph Garbers,Christoph Garbers +6 more
TL;DR: In this paper, the authors analyzed the contribution of IL-11 signaling on monocyte recruitment and monocyte infection in a mouse model of cutaneous leishmaniasis and found that IL11 signaling is dispensable for monocyte activation and pathogen uptake during Leishmania major infection.
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