Irina Petrache
University of Colorado Denver
214 Papers
1.3K Citations
Irina Petrache is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Medicine & Lung. The author has an hindex of 51, co-authored 181 publications. Previous affiliations of Irina Petrache include Veterans Health Administration & Indiana University – Purdue University Indianapolis.
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Papers
Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis
Hongyan Lu,Christophe Poirier,Todd Cook,Dmitry O. Traktuev,Stephanie Merfeld-Clauss,Benjamin R. Lease,Irina Petrache,Keith L. March,Natalia V. Bogatcheva +8 more
TL;DR: Factors secreted by ASC efficiently reduce ARDS indices, endothelial barrier hyperpermeability, and activation of pro-inflammatory and pro-apoptotic pathways in endothelium.
Inhibition of Acid Sphingomyelinase Disrupts LYNUS Signaling and Triggers Autophagy
Matthew J. Justice,Irina Bronova,Kelly S. Schweitzer,Christophe Poirier,Janice S. Blum,Evgeny Berdyshev,Irina Petrache +6 more
TL;DR: In this paper, the role of acid sphingomyelinase (ASM) activity in maintaining physiological functions of lysosomes was investigated, focusing on the Lysosomal nutrient-sensing complex (LYNUS).
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MicroRNA-126-3p Inhibits Angiogenic Function of Human Lung Microvascular Endothelial Cells via LAT1 (L-Type Amino Acid Transporter 1)-Mediated mTOR (Mammalian Target of Rapamycin) Signaling
Danting Cao,Andrew M. Mikosz,Alexandra J. Ringsby,Kelsey C. Anderson,Erica L. Beatman,Kengo Koike,Irina Petrache +6 more
TL;DR: The effect of miR-126 on HLMVEC angiogenesis was mediated by the LAT1 (L-type amino acid transporter 1), via regulation of mTOR (mammalian target of rapamycin) signaling, which inhibited cell apoptosis and improved endothelial tube formation during exposure to environmental insults such as cigarette smoke.
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Cigarette Smoke–Induced CXCR3 Receptor Up-Regulation Mediates Endothelial Apoptosis
Linden A. Green,Daniela N. Petrusca,Gangaraju Rajashekhar,Tom Gianaris,Kelly S. Schweitzer,Liang Wang,Matthew J. Justice,Irina Petrache,Matthias Clauss +8 more
TL;DR: The concerted up-regulation of proinflammatory EMAP II, IP-10, and CXCR3 by cigarette smoke could sustain a cascade of cell death that may promote the alveolar tissue loss noted in human emphysema.
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Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.
Andrea L. Frump,Mona Selej,Jordan A. Wood,Marjorie Albrecht,Bakhtiyor Yakubov,Irina Petrache,Tim Lahm,Tim Lahm +7 more
TL;DR: The results demonstrate a novel and potentially therapeutically targetable mechanism whereby hypoxia, via HIF‐1&agr;, increases ER&bgr; expression and the E2‐ER&b gr; axis targets PHD2, Hif‐1 &agR;, and H IF‐2&ag r; to attenuate HPH development.