Irina Lehmann
Humboldt University of Berlin
231 Papers
1.5K Citations
Irina Lehmann is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 50, co-authored 226 publications. Previous affiliations of Irina Lehmann include Charité & Norwegian Institute of Public Health.
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Papers
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Christiane A. Opitz,Ulrike M. Litzenburger,Ulrike M. Litzenburger,Felix Sahm,Martina Ott,Isabel Tritschler,Saskia Trump,Theresa Schumacher,Theresa Schumacher,Leonie Jestaedt,Dieter Schrenk,Michael Weller,Manfred Jugold,Gilles J. Guillemin,Christine L. Miller,Christian Lutz,Bernhard Radlwimmer,Irina Lehmann,Andreas von Deimling,Wolfgang Wick,Michael Platten +20 more
TL;DR: Evidence is provided for a previously unidentified pathophysiological function of the AHR that is constitutively generated by human tumours via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology.
1.7K
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Maria Theresa Völker,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Melanie Maier,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Norbert Suttorp,Jürgen Eils,Naveed Ishaque,Uwe G. Liebert,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif E. Sander,Roland Eils,Roland Eils +37 more
TL;DR: The data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19, which likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure.
Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
LifeCycle Project-Maternal Obesity,Ellis Voerman,Susana Santos,Susana Santos,Hazel Inskip,Pilar Amiano,Henrique Barros,Henrique Barros,Marie-Aline Charles,Marie-Aline Charles,Marie-Aline Charles,Leda Chatzi,George P. Chrousos,Eva Corpeleijn,Sarah Crozier,Myriam Doyon,Merete Eggesbø,Maria Pia Fantini,Sara Farchi,Francesco Forastiere,Vagelis Georgiu,Davide Gori,Wojciech Hanke,Irva Hertz-Picciotto,Irva Hertz-Picciotto,Barbara Heude,Barbara Heude,Marie-France Hivert,D. Hryhorczuk,Carmen Iñiguez,Anne M. Karvonen,Leanne K. Küpers,Hanna Lagström,Debbie A Lawlor,Irina Lehmann,Per Magnus,Renata Majewska,Johanna Mäkelä,Yannis Manios,Monique Mommers,Monique Mommers,Camilla Schmidt Morgen,George Moschonis,Ellen A. Nohr,Anne-Marie Nybo Andersen,Emily Oken,Agnieszka Pac,Eleni Papadopoulou,Eleni Papadopoulou,Juha Pekkanen,Costanza Pizzi,Kinga Polańska,Daniela Porta,Lorenzo Richiardi,Sheryl L. Rifas-Shiman,Nel Roeleveld,L. Ronfani,Ana Cristina Santos,M. Standl,Hein Stigum,Hein Stigum,Camilla Stoltenberg,E. Thiering,Carel Thijs,Maties Torrent,Tomas Trnovec,Marleen M.H.J. van Gelder,Lenie van Rossem,Andrea von Berg,Martine Vrijheid,Alet H. Wijga,Oleksandr Zvinchuk,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Keith M. Godfrey,Vincent W. V. Jaddoe,Romy Gaillard +76 more
TL;DR: In this meta-analysis of pooled individual participant data from 25 cohort studies, the risk for adverse maternal and infant outcomes varied by gestational weight gain and across the range of prepregnancy weights, however, the optimal gestations weight gain ranges had limited predictive value for the outcomes assessed.
Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts
Susana Santos,Ellis Voerman,Pilar Amiano,Henrique Barros,Lawrence J. Beilin,Anna Bergström,Marie-Aline Charles,Leda Chatzi,Cécile Chevrier,George P. Chrousos,Eva Corpeleijn,Olga Costa,Nathalie Costet,Sarah Crozier,Graham Devereux,Myriam Doyon,Merete Eggesbø,Maria Pia Fantini,Sara Farchi,Francesco Forastiere,Vagelis Georgiu,Keith M. Godfrey,Davide Gori,Veit Grote,Wojciech Hanke,Irva Hertz-Picciotto,Barbara Heude,Marie-France Hivert,Daniel O. Hryhorczuk,Rae-Chi Huang,Hazel Inskip,Anne M. Karvonen,Louise C. Kenny,Berthold Koletzko,Leanne K. Küpers,Hanna Lagström,Irina Lehmann,Per Magnus,Renata Majewska,Johanna Mäkelä,Yannis Manios,Fionnuala M. McAuliffe,Sheila McDonald,John Mehegan,Erik Melén,Monique Mommers,Camilla Schmidt Morgen,George Moschonis,Deirdre M. Murray,Carol Ní Chaoimh,Ellen A. Nohr,Anne-Marie Nybo Andersen,Emily Oken,Adriëtte J J M Oostvogels,Agnieszka Pac,Eleni Papadopoulou,Juha Pekkanen,Costanza Pizzi,Kinga Polańska,Daniela Porta,Lorenzo Richiardi,Sheryl L. Rifas-Shiman,Nel Roeleveld,Luca Ronfani,Ana Cristina Santos,Marie Standl,Hein Stigum,Camilla Stoltenberg,Elisabeth Thiering,Carel Thijs,Maties Torrent,Suzanne Tough,Tomas Trnovec,Steve Turner,Marleen M.H.J. van Gelder,Lenie van Rossem,Andrea von Berg,Martine Vrijheid,Tanja G. M. Vrijkotte,Jane West,Alet H. Wijga,John Wright,Oleksandr Zvinchuk,Thorkild I. A. Sørensen,Debbie A Lawlor,Romy Gaillard,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe +87 more
TL;DR: In this paper, the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact were assessed.
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Maternal body mass index, gestational weight gain and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
Ellis Voerman,Susana Santos,Bernadeta Patro Golab,Bernadeta Patro Golab,Pilar Amiano,Ferran Ballester,Henrique Barros,Anna Bergström,Marie-Aline Charles,Marie-Aline Charles,Leda Chatzi,Leda Chatzi,Leda Chatzi,Cécile Chevrier,George P. Chrousos,Eva Corpeleijn,Nathalie Costet,Sarah Crozier,Graham Devereux,Merete Eggesbø,Sandra Ekström,Maria Pia Fantini,Sara Farchi,Francesco Forastiere,Vagelis Georgiu,Keith M. Godfrey,Keith M. Godfrey,Davide Gori,Veit Grote,Wojciech Hanke,Irva Hertz-Picciotto,Barbara Heude,Barbara Heude,Daniel O. Hryhorczuk,Rae-Chi Huang,Hazel Inskip,Hazel Inskip,Nina Iszatt,Anne M. Karvonen,Louise C. Kenny,Berthold Koletzko,Leanne K. Küpers,Hanna Lagström,Irina Lehmann,Per Magnus,Renata Majewska,Johanna Mäkelä,Yannis Manios,Fionnuala M. McAuliffe,Sheila McDonald,John Mehegan,Monique Mommers,Camilla Schmidt Morgen,Camilla Schmidt Morgen,Trevor A. Mori,George Moschonis,Deirdre M. Murray,Carol Ní Chaoimh,Ellen A. Nohr,Anne-Marie Nybo Andersen,Emily Oken,Adriette J. J. M. Oostvogels,Agnieszka Pac,Eleni Papadopoulou,Juha Pekkanen,Costanza Pizzi,Kinga Polańska,Daniela Porta,Lorenzo Richiardi,Sheryl L. Rifas-Shiman,Luca Ronfani,Ana Cristina Santos,Marie Standl,Camilla Stoltenberg,Elisabeth Thiering,Carel Thijs,Maties Torrent,Suzanne Tough,Tomas Trnovec,Steve Turner,Lenie van Rossem,Andrea von Berg,Martine Vrijheid,Tanja G. M. Vrijkotte,Jane West,Alet H. Wijga,John Wright,Oleksandr Zvinchuk,Thorkild I. A. Sørensen,Debbie A Lawlor,Romy Gaillard,Vincent W. V. Jaddoe +91 more
TL;DR: In this article, the authors conducted an individual participant data meta-analysis of data from 162,129 mothers and children from 37 pregnancy and birth cohort studies from Europe, North-America and Australia, using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal socio-demographic and life style related characteristics.