Irina Borodina
Technical University of Denmark
117 Papers
384 Citations
Irina Borodina is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Yeast & Yarrowia. The author has an hindex of 34, co-authored 96 publications. Previous affiliations of Irina Borodina include Novo Nordisk Foundation.
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Papers
Improvement of cis, cis-Muconic Acid Production in Saccharomyces cerevisiae through Biosensor-Aided Genome Engineering
Guokun Wang,Süleyman Øzmerih,Rogério Guerreiro,Ana C Meireles,Ana Carolas,Nicholas Milne,Michael Krogh Jensen,Bruno Sommer Ferreira,Irina Borodina +8 more
TL;DR: The Mut131 strain was rationally engineered by overexpression of the genes encoding for PCA decarboxylase and AROM protein without shikimate dehydrogenase domain, and by restoring URA3 prototrophy, representing the highest reported performance metrics in a yeast for de novo CCM production to date and the highest production of an aromatic compound in yeast.
Understanding metabolite transport gives an upper hand in strain development
TL;DR: Cell factories can be engineered for more efficient product secretion through modulation of membrane transporters to improve the efficiency of product secretion.
HOG-Independent Osmoprotection by Erythritol in Yeast Yarrowia lipolytica.
TL;DR: The deletion of two genes involved in erythritol utilization, the transcription factor Euf1 and the enzyme erystritol dehydrogenase Eyd1, indicates that Euf 1 regulates additional, still unknown genes involved with eryTHritol metabolism in Yarrowia lipolytica under hyperosmotic stress.
Screening of Saccharomyces cerevisiae metabolite transporters by 13C isotope substrate labeling
Lyubomir Dimitrov Stanchev,Iben Møller-Hansen,Pawel Lojko,Catarina Rocha,Irina Borodina +4 more
TL;DR: The application of 13C-labeled stable isotopes and detection by targeted LC–MS/MS as a screening tool for identifying Saccharomyces cerevisiae metabolite transporters demonstrates the application of a comprehensive screening platform for the knowledge expansion of the transporter-substrate relationship for native metabolites in S. Cerevisiae.
Glucose-Dependent Promoters for Dynamic Regulation of Metabolic Pathways.
Jerome Maury,Soumya Kannan,Niels Bjerg Jensen,Fredrik Öberg,Kanchana Rueksomtawin Kildegaard,Jochen Förster,Jens Nielsen,Christopher T. Workman,Irina Borodina +8 more
TL;DR: This work identified 34 candidate promoters that strongly responded to glucose presence or absence and characterized these promoters in small-scale batch and fed-batch cultivations using a quickly maturing rapidly degrading green fluorescent protein yEGFP3-Cln2PEST as a reporter.