Irfan Rahman
University of Rochester Medical Center
368 Papers
2.8K Citations
Irfan Rahman is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Medicine & Oxidative stress. The author has an hindex of 93, co-authored 325 publications. Previous affiliations of Irfan Rahman include Novartis & Edinburgh Royal Infirmary.
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Papers
Modulation of steroid activity in chronic inflammation : A novel anti-inflammatory role for curcumin
Saibal K. Biswas,Irfan Rahman +1 more
TL;DR: Curcumin, a polyphenol present in the spice turmeric, may be a potential antioxidant and anti-inflammatory therapeutic agent against chronic inflammatory lung diseases.
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•Journal Article
Future therapeutic treatment of COPD: struggle between oxidants and cytokines.
TL;DR: This review highlights studies on novel or potential drug antioxidants such as dietary antioxidants supplementation, N-acetyl-L-cysteine,N-acystelyn, endosteine, antioxidant enzyme mimetics, and anti-inflammatory agents like antagonists of cytokines, such as tumor necrosis factor (TNF)-α, CXCL8, and CCL2, and inhibitors of signal transduction proteins including phosphodiesterase 4, MAPK p38, Pl-3k
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Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers.
Naushad Ahmad Khan,Gina Lawyer,Samantha R. McDonough,Qixin Wang,Noura O Kassem,Flora Kas-Petrus,Dongxia Ye,Kameshwar P. Singh,Irfan Rahman +8 more
TL;DR: Biomarkers of inflammation, oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups, and concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone.
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Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
TL;DR: It is shown that p50 endogenously regulates the activity of RelA/p65 by decreasing its phosphoacetylation and DNA binding activity and specific histone modifications and that genetic ablation of p50 leads to air space enlargement in mouse.
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Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer
Isaac K. Sundar,Irfan Rahman +1 more
TL;DR: CS-induced genotoxic stress differentially affects the expression of epigenetic modulators that regulate transcription of target genes via DNA methylation and site-specific histone modifications, which may have implications in devising epigenetic-based therapies for COPD and lung cancer.