5 Papers
54 Citations
Irene Pais is an academic researcher from Instituto Português de Oncologia Francisco Gentil. The author has contributed to research in topics: DNA methylation & Prostate. The author has an hindex of 4, co-authored 5 publications.
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Papers
Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis.
Rui Henrique,Carmen Jerónimo,Carmen Jerónimo,Carmen Jerónimo,Manuel R. Teixeira,Manuel R. Teixeira,Mohammad O. Hoque,André Lopes Carvalho,Irene Pais,Franclim R. Ribeiro,Jorge Oliveira,Carlos Lopes,David Sidransky +12 more
TL;DR: It is concluded that APC and RARβ2 hypermethylation is frequent in normal prostate tissue and the progressive enrichment in cells carrying methylated alleles observed in high-grade PIN and prostate carcinoma is consistent with clonal progression.
93
Aberrant cellular retinol binding protein 1 (CRBP1) gene expression and promoter methylation in prostate cancer.
Carmen Jerónimo,Rui Henrique,Jorge Oliveira,Francisco S. N. Lobo,Irene Pais,Manuel R. Teixeira,Carla Lopes +6 more
TL;DR: Altered CRBP1 expression and hypermethylation are common in prostate carcinoma, althoughCRBP1 hyper methylmethylation is not an early event in tumorigenesis, and both adenocarcinoma and HGPIN show frequent CR BP1 overexpression.
64
Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions
Carmen Jerónimo,Carmen Jerónimo,Paula Monteiro,Rui Henrique,Mário Dinis-Ribeiro,Isabel Costa,Vera Costa,Luísa Filipe,André Lopes Carvalho,Mohammad O. Hoque,Irene Pais,C. Leal,Manuel R. Teixeira,David Sidransky +13 more
TL;DR: Evidence is provided that multigene methylation analysis augments diagnostic accuracy of cytological assessment of suspicious breast lesions, and might be a valuable ancillary tool for breast cancer diagnosis.
55
Mitochondrial genome alterations in rectal and sigmoid carcinomas.
Manuela Pinheiro,Isabel Veiga,Carla M. A. Pinto,Luís Pedro Afonso,Olga Sousa,Maria Candida Barisson Villares Fragoso,Lúcio Lara Santos,Paula Lopes,Irene Pais,Carlos Lopes,Manuel R. Teixeira +10 more
TL;DR: In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis and a trend toward an association between nuclear and mitochondrial microsatellite instability was observed.
22
Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples
Inês Moura,Vera Costa,Irene Pais,Franclim R. Ribeiro,Rui Henrique,Carmen Jerónimo +5 more
- 01 Jan 2008
TL;DR: The results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of p-gp expression regulation and will be able to evaluate the impact of these results in the treatment of pca patients.