Irene Buzzacchera
University of Pennsylvania
8 Papers
Irene Buzzacchera is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chemistry & Self-healing hydrogels. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Irene Buzzacchera include Leibniz Association & RWTH Aachen University.
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Papers
Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating.
Alicja E. Kownacka,Dovile Vegelyte,Maurits Joosse,Nicoleta Anton,B. Jelle Toebes,Jan Lauko,Irene Buzzacchera,Katarzyna Lipinska,Daniela A. Wilson,Nel Geelhoed-Duijvestijn,Christopher J. Wilson +10 more
TL;DR: The NovioSense Glucose Sensor, worn under the lower eye lid (inferior conjunctival fornix), is reported to continuously measure glucose levels in the basal tear fluid with good correlation to blood glucose values, showing clear clinical feasibility in both animals and humans.
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Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings
Irene Buzzacchera,Mariia Vorobii,Nina Yu. Kostina,Andres de los Santos Pereira,Tomáš Riedel,Michael Bruns,Wojciech Ogieglo,Martin Möller,Christopher J. Wilson,Cesar Rodriguez-Emmenegger +9 more
TL;DR: This methodology offers a facile route to functionalizing implantable sensor systems with antifouling coatings that improve hemocompatibility and pave the way for enhanced device integration in tissue.
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Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes.
Qi Xiao,Anna-Kristin Ludwig,Cecilia Romanò,Irene Buzzacchera,Irene Buzzacchera,Samuel E. Sherman,M. Vetro,Sabine Vértesy,Herbert Kaltner,Ellen H. Reed,Martin Möller,Christopher J. Wilson,Daniel A. Hammer,Stefan Oscarson,Michael L. Klein,Hans-Joachim Gabius,Virgil Percec +16 more
TL;DR: How synthetic JGD-headgroup tailoring teamed with protein engineering and network assays can help explain how molecular matchmaking operates in the cellular context of glycan and lectin complexity is demonstrated.
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Encoding biological recognition in a bicomponent cell-membrane mimic.
Cesar Rodriguez-Emmenegger,Qi Xiao,Qi Xiao,Nina Yu. Kostina,Samuel E. Sherman,Khosrow Rahimi,Benjamin E. Partridge,Shangda Li,Dipankar Sahoo,Aracelee M. Reveron Perez,Irene Buzzacchera,Irene Buzzacchera,Hong Han,Meir Kerzner,Ishita Malhotra,Martin Möller,Christopher J. Wilson,Matthew C. Good,Mark Goulian,Tobias Baumgart,Michael L. Klein,Virgil Percec +21 more
TL;DR: The discovery of lamellar and hexagonal periodic arrays on the surface of vesicles generated from sequence-defined bicomponent monodisperse oligomers containing lipid and glycolipid mimics provides a mechanism to encode the reactivity of sugars via their interaction with sugar-binding proteins.
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Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids
Paola Torre,Qi Xiao,Qi Xiao,Irene Buzzacchera,Irene Buzzacchera,Samuel E. Sherman,Khosrow Rahimi,Khosrow Rahimi,Nina Yu. Kostina,Nina Yu. Kostina,Cesar Rodriguez-Emmenegger,Cesar Rodriguez-Emmenegger,Martin Möller,Martin Möller,Christopher J. Wilson,Michael L. Klein,Matthew C. Good,Virgil Percec +17 more
TL;DR: It is reported that vesicles self-assembled from amphiphilic Janus dendrimers, called d endrimersomes, encapsulate high concentrations of hydrophobic components and do so more efficiently than commercially available stealth liposomes assembled from phospholipid components.
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