Irene Brunk
Charité
18 Papers
135 Citations
Irene Brunk is an academic researcher from Charité. The author has contributed to research in topics: Synaptic vesicle & Monoamine neurotransmitter. The author has an hindex of 11, co-authored 18 publications.
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Papers
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Gabriele Hampp,Jürgen A. Ripperger,Thijs Houben,Isabelle Schmutz,Christian Blex,Stephanie Perreau-Lenz,Irene Brunk,Rainer Spanagel,Gudrun Ahnert-Hilger,Johanna H. Meijer,Urs Albrecht +10 more
TL;DR: A role of circadian-clock components in dopamine metabolism highlighting a role of the clock in regulating mood-related behaviors is suggested.
418
Differential Sorting of the Vesicular Glutamate Transporter 1 into a Defined Vesicular Pool Is Regulated by Light Signaling Involving the Clock Gene Period2
Sowmya V. Yelamanchili,Gurudutt Pendyala,Irene Brunk,Mahesh Darna,Urs Albrecht,Gudrun Ahnert-Hilger +5 more
TL;DR: It is concluded that nerve terminals are endowed with mechanisms that regulate quantal size by changing the copy number of transporters in synaptic vesicles, and a reduced amount of VGLUT1 per vesicle is probably achieved by means of selective sorting controlled by clock genes.
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Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.
TL;DR: It is concluded that CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2.
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Age-dependent axonal expression of potassium channel proteins during development in mouse hippocampus
TL;DR: Studying the expression of several voltage-gated potassium channel proteins during hippocampal development in vivo and in primary cultures offers a new approach to functionally distinguish classes of hippocampal neurons and may extend the understanding of hippocampusal circuitry and memory processing.
31
Regulation of vesicular monoamine and glutamate transporters by vesicle-associated trimeric G proteins: new jobs for long-known signal transduction molecules.
Irene Brunk,M. Höltje,B. von Jagow,Sandra Winter,J. Sternberg,C. Blex,Ingrid Pahner,Gudrun Ahnert-Hilger +7 more
TL;DR: It appears that the vesicular content activates the G protein, suggesting a signal transduction from the luminal site which might be mediated by a vesicle G protein-coupled receptor or as an alternative possibility by the transporter itself.
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