Ira Pastan
Laboratory of Molecular Biology
1304 Papers
37.6K Citations
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Papers
Amatuximab, a chimeric monoclonal antibody to mesothelin, in combination with pemetrexed and cisplatin in patients with unresectable pleural mesothelioma: Results of a multicenter phase II clinical trial.
Raffit Hassan,Thierry Jahan,Hedy L. Kindler,Lyudmila Bazhenova,Martin Reck,Ira Pastan,Alison Ellis,Penny Marie Fatato,John W. Heyburn,Charles Schweizer,Jeff Parno,Bruce A. Wallin +11 more
TL;DR: A single arm phase II study of amatuximab plus pemetrexed and cisplatin in patients with unresectable epithelial or biphasic pleural malignant mesothelioma found it to be a safe and effective treatment for patients with objective response or stable disease.
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Patent
Human anti-mesothelin monoclonal antibodies
Dimiter S. Dimitrov,Yang Feng,Ira Pastan +2 more
- 25 Mar 2009
TL;DR: In this article, isolated human monoclonal antibodies that specifically bind human mesothelin with a binding affinity of about 25 nM or less were presented, and methods of diagnosing cancer, or confirming a diagnosis of cancer, were also disclosed.
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Use of Pseudomonas aeruginosa Toxin A in the Construction of Conjugate Vaccines and Immunotoxins
S. J. Cryz,E. Fiirer,J. C. Sadoff,R. Germanier,Ira Pastan,Mark C. Willingham,Desmond J. Fitzgerald +6 more
TL;DR: Pseudomonas aeruginosa toxin A was used to construct conjugate vaccines and potent cytotoxic immunotoxins and antitumor activity was demonstrated when the immunotoxin directed against the transferrin receptor was administered to nude mice bearing human ovarian tumors.
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Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach.
TL;DR: The conclusion is supported that, in CHO cells, the presence of a normally functioning cAMP-dependent protein kinase appears to be necessary but may not be sufficient to observe the effects of cAMP on nutrient transport as well as cell shape and cell growth.
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Morphologic Methods in the Study of Endocytosis in Cultured Cells
Mark C. Willingham,Ira Pastan +1 more
- 01 Jan 1985
TL;DR: This chapter describes methods with which the author has had direct experience, many of which are in common use in the study of the internalization of ligands by cultured cells.
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