Ira Pastan
Laboratory of Molecular Biology
1304 Papers
37.6K Citations
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Papers
Inhibition of the transformation-specific kinase in ASV-transformed cells by N-α-tosyl-L-lysyl chloromethyl ketone
TL;DR: The finding that the inhibition of the kinase by TLCK in vivo parallels the reversion of cell morphology to normal suggests that the Kinase has an important role in transformation and offers a biochemical rationale for treatment of tumors with this agent.
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Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and tcr fv frameworks are very similar in structure
Yoram Reiter,Istvan Kurucz,Ulrich Brinkmann,Sun-Hee Jung,Byungkook Lee,David M. Segal,Ira Pastan +6 more
TL;DR: These results provide very strong experimental evidence for the structural similarity between immunoglobulin and TCR antigen-binding variable domains.
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IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.
H. Lorberboum-Galski,R. J. Garsia,Maurice K. Gately,P. S. Brown,Richard E. Clark,Thomas A. Waldmann,Vijay K. Chaudhary,Desmond J. Fitzgerald,Ira Pastan +8 more
TL;DR: The results indicate that IL2-PE664Glu should be evaluated as an immunosuppressive agent for the treatment of human immune disorders in which activated T cells expressing the IL2 receptor are prominent.
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In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells.
TL;DR: A potentially expanded role of recombinant toxin therapy in restenosis is suggested: multiple receptors can be targeted, and cytotoxic effects can be preferentially directed to rapidly proliferating vascular SMCs, with relative sparing of vascular endothelial cells.
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Specific Killing of HIV-infected Lymphocytes by a Recombinant Immunotoxin Directed against the HIV-1 Envelope Glycoprotein
TL;DR: Potent immunotoxins such as 3B3(Fv)-PE38 could be utilized in combination with multidrug cocktails that limit viral replication to help reduce viral reservoirs in patients with AIDS.