Ira Fleming
Massachusetts Institute of Technology
11 Papers
6 Citations
Ira Fleming is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 2, co-authored 7 publications. Previous affiliations of Ira Fleming include Harvard University & Ragon Institute of MGH, MIT and Harvard.
Chat about Author
Papers
Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity.
Dania Zhivaki,Francesco Borriello,Ohn A. Chow,Benjamin Doran,Ira Fleming,Ira Fleming,Ira Fleming,Derek J. Theisen,Paris Pallis,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Caroline L. Sokol,Ivan Zanoni,Jonathan C. Kagan +14 more
TL;DR: It is reported that hyperactive DCs have an enhanced ability to migrate to draining lymph nodes and stimulate potent cytotoxic T lymphocyte (CTL) responses, dependent on the chemokine receptor CCR7 and associated with a unique transcriptional program that is not observed in conventionally activated or pyroptotic DCs.
123
Functional compensation precedes recovery of tissue mass following acute liver injury.
Chad Walesky,Kellie E. Kolb,Kellie E. Kolb,Kellie E. Kolb,Carolyn Winston,Jake Henderson,Benjamin Kruft,Ira Fleming,Ira Fleming,Ira Fleming,Sungjin Ko,Satdarshan P.S. Monga,Florian Mueller,Udayan Apte,Alex K. Shalek,Wolfram Goessling +15 more
TL;DR: Overall, this work describes a mechanism by which the liver maintains essential physiological functions prior to cellular reconstitution and characterizes macrophage-derived WNT signals required for this compensation.
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
Conner Kummerlowe,Simutanyi Mwakamui,Travis K. Hughes,Nolawit Mulugeta,Victor Mudenda,Ellen Besa,Kanekwa Zyambo,Jessica E.S. Shay,Ira Fleming,Marko Vukovic,Benjamin Doran,Toby Aicher,Marc H. Wadsworth,Juliet Bramante,Amiko M. Uchida,Rabiah Fardoos,Osaretin E. Asowata,N. Herbert,Ömer H. Yilmaz,Henrik N. Kløverpris,John J. Garber,Jose Ordovas-Montanes,Zev J. Gartner,Thomas Dr. Wallach,Alex K. Shalek,Paul J. Kelly +25 more
TL;DR: The cellular and molecular correlates of EE are mapped by performing high-throughput, single-cell RNA-sequencing on 33 small intestinal biopsies from 11 adults with EE in Lusaka, Zambia, six adults without EE in Boston, United States, and two adults in Durban, South Africa, which are complemented with published data from three additional individuals from the same clinical site.
20
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
Ruoyi Jiang,Hailong Meng,Khadir Raddassi,Ira Fleming,Kenneth B. Hoehn,Kenneth R. Dardick,Alexia A. Belperron,Ruth R. Montgomery,Alex K. Shalek,David A. Hafler,Steven H. Kleinstein,Linda K. Bockenstedt +11 more
TL;DR: This article used single-cell RNA-Seq in conjunction with B cell receptor (BCR) sequencing to immunophenotype erythema migrans (EM) lesions and their associated B cells and BCR repertoires.
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients.
Alex S. Genshaft,Sonu Subudhi,Arlin Keo,Juan Diego Sanchez Vasquez,Deeqa Mahamed,Lauke L. Boeijen,Nadia Alatrakchi,Chris Oetheimer,Mike Vilme,Riley S. Drake,Ira Fleming,Nancy Tran,Constantine N. Tzouanas,Jasmin Joseph-Chazan,Martin Arreola Villanueva,H. van de Werken,Gertine W. van Oord,Zwier M. A. Groothuismink,Boris J. B. Beudeker,Zgjim Osmani,Shirin Nkongolo,Aman Mehrotra,Kurt Spittaels,Jordan J. Feld,Raymond T. Chung,Robert J. de Knegt,Harry L.A. Janssen,Jeroen Aerssens,Jacques A. Bollekens,Nir Hacohen,Georg M. Lauer,Andre Boonstra,Alex K. Shalek,Adam J. Gehring +33 more
TL;DR: In this article , the authors developed a workflow that enabled multi-site international studies and centralized scRNAseq to identify biomarkers for intrahepatic immune activity in chronic hepatitis B (CHB) patients.
15