Ioannis Tassiulas
University of Crete
16 Papers
157 Citations
Ioannis Tassiulas is an academic researcher from University of Crete. The author has contributed to research in topics: Cytokine & Systemic lupus erythematosus. The author has an hindex of 15, co-authored 16 publications. Previous affiliations of Ioannis Tassiulas include National Institutes of Health & Hospital for Special Surgery.
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Papers
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs
George Bertsias,John P. A. Ioannidis,Martin Aringer,Edward L.E.M. Bollen,Stefano Bombardieri,Ian N. Bruce,Ricard Cervera,Marinos C. Dalakas,Andrea Doria,John G. Hanly,Twj Huizinga,David A. Isenberg,C. G. M. Kallenberg,J.C. Piette,Matthias Schneider,N Scolding,Josef S Smolen,A Stara,Ioannis Tassiulas,Maria G Tektonidou,Angela Tincani,M.A. van Buchem,R. van Vollenhoven,M. M. Ward,Caroline Gordon,Dimitrios T. Boumpas +25 more
TL;DR: Neuropsychiatric manifestations in SLE patients should be first evaluated and treated as in patients without SLE, and secondarily attributed to SLE and treated accordingly.
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IFN-α Priming Results in a Gain of Proinflammatory Function by IL-10: Implications for Systemic Lupus Erythematosus Pathogenesis
M. Nusrat Sharif,Ioannis Tassiulas,Yang Hu,Ingrid Mecklenbräuker,Alexander Tarakhovsky,Lionel B. Ivashkiv +5 more
TL;DR: It is demonstrated that type I IFNs regulate the balance between IL-10 anti- and proinflammatory activity, and insight into molecular mechanisms that regulate IL- 10 function is provided.
136
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Lu Wang,Ioannis Tassiulas,Ioannis Tassiulas,Kyung-Hyun Park-Min,Alicia C. Reid,Hava Gil-Henn,Joseph Schlessinger,Roland Baron,J. Jillian Zhang,Lionel B. Ivashkiv,Lionel B. Ivashkiv +10 more
TL;DR: The function of the calcium-dependent kinases CaMK and Pyk2 'downstream' of ITAM-associated receptors in the regulation of cytokine-induced activation of Jak kinases and STAT transcription factors is investigated.
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Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.
Ioannis Tassiulas,Kyung-Hyun Park-Min,Yang Hu,Lisa Kellerman,Dror Mevorach,Lionel B. Ivashkiv,Lionel B. Ivashkiv +6 more
TL;DR: The suppressive effects of apoptotic cells on signal transduction are identified, and the understanding of the anti-inflammatory effects of apoptotic cells to include suppression of Jak-STAT signaling is extended.
53
Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus.
Magdalene Nakou,George Bertsias,Ilias Stagakis,Michael Centola,Ioannis Tassiulas,Maria Hatziapostolou,Iraklis Kritikos,George N. Goulielmos,Dimitrios T. Boumpas,Dimitrios Iliopoulos +9 more
TL;DR: Gene network analysis of lupus BMMCs identified central gene regulators implicated in disease pathogenesis which could represent targets of novel therapies in human SLE.