Inge Krebs
German Cancer Research Center
10 Papers
159 Citations
Inge Krebs is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Carcinogenesis & Tumor suppressor gene. The author has an hindex of 10, co-authored 10 publications. Previous affiliations of Inge Krebs include Odense University Hospital.
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Papers
•Journal Article
DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.
Jan Mollenhauer,Stephan Herbertz,Uffe Holmskov,Markus Tolnay,Inge Krebs,Adrian Merlo,Henrik Daa Schrøder,Daniel Maier,Frank Breitling,Stefan Wiemann,Hermann Josef Gröne,Annemarie Poustka +11 more
TL;DR: DMBT1 is a gene that is highly unstable in cancer and encodes for a protein with at least two different functions, one in the immune defense and a second one in epithelial differentiation, according to expression analyses and studies with a monoclonal antibody against the protein.
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.
Leena Karenko,Sonja Hahtola,Suvi Päivinen,Ritva Karhu,Sanna Syrjä,Marketta Kähkönen,Bogusław Nedoszytko,Soili Kytölä,Ying Zhou,Vesna Blazevic,Maria Pesonen,Hanna Nevala,Nina N. Nupponen,Harri Sihto,Inge Krebs,Annemarie Poustka,Jadwiga Roszkiewicz,Kalle Saksela,Pärt Peterson,Tapio Visakorpi,Annamari Ranki +20 more
TL;DR: NAV3, a novel putative haploinsufficient tumor suppressor gene, is disrupted in most cases of the commonest types of CTCL and may thus provide a new diagnostic tool.
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The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.
Jan Mollenhauer,Uffe Holmskov,Stefan Wiemann,Inge Krebs,Stephan Herbertz,Jens Madsen,Petra Kioschis,Johannes F. Coy,Annemarie Poustka +8 more
TL;DR: The data suggest that alternative splicing gives rise to isoforms of DMBT1 with a differential utilization of SRCR domains and S RCR interspersed domains, and the major part of the gene harbours locus specific repeats, which may point to the D MBT1 locus as a region susceptible to chromosomal instability.
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CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D.
Jens Madsen,Ida Tornøe,Ole Haagen Nielsen,Mette Lausen,Inge Krebs,Jan Mollenhauer,Gaby Kollender,Annemarie Poustka,Karsten Skjødt,Uffe Holmskov +9 more
TL;DR: It is concluded that CRP‐ductin is the mouse homologue of human gp‐340 and that its capacity to bind SP‐D as well as gram‐negative and gram‐positive bacteria suggests a role in mucosal immune defense.
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Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas
Jan Mollenhauer,Burkhard Helmke,Hanna Müller,Gaby Kollender,Stefan Lyer,Laura Diedrichs,Uffe Holmskov,Toon Ligtenberg,Stephan Herbertz,Inge Krebs,Stefan Wiemann,Jens Madsen,Floris J. Bikker,Liane Schmitt,Herwart F. Otto,Annemarie Poustka +15 more
TL;DR: It is hypothesized that the changes of the DMBT1 expression and location do reflect a time course that may point to possible mechanisms for its role in epithelial cancer.
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