Inge Huitinga
University of Amsterdam
20 Papers
154 Citations
Inge Huitinga is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Microglia & Multiple sclerosis. The author has an hindex of 10, co-authored 20 publications. Previous affiliations of Inge Huitinga include Netherlands Institute for Neuroscience & Royal Netherlands Academy of Arts and Sciences.
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Papers
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
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Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
Marlijn van der Poel,Thomas Ulas,Mark R. Mizee,Cheng-Chih Hsiao,Suzanne S. M. Miedema,Adelia,Karianne G. Schuurman,Boy Helder,Sander W. Tas,Joachim L. Schultze,Joachim L. Schultze,Jörg Hamann,Jörg Hamann,Inge Huitinga +13 more
TL;DR: Significant intrinsic differences in the human microglial transcriptome between grey and white matter regions are demonstrated, isolated from MS and non-neurological control donors, and show early microglia changes related to MS pathology.
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions
Nina L. Fransen,Cheng-Chih Hsiao,Marlijn van der Poel,Hendrik J Engelenburg,Kim Verdaasdonk,Maria C J Vincenten,Ester B. M. Remmerswaal,Tanja Kuhlmann,Matthew R. J. Mason,Jörg Hamann,Jörg Hamann,Joost Smolders,Joost Smolders,Inge Huitinga,Inge Huitinga +14 more
TL;DR: Data show that in chronic progressive multiple sclerosis cases, inflammatory lesion activity and demyelinated lesion load is associated with an increased number of T cells clustering in the perivascular space.
Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions
Debbie A.E. Hendrickx,Jackelien van Scheppingen,Marlijn van der Poel,Koen Bossers,Karianne G. Schuurman,Corbert G. van Eden,Elly M. Hol,Elly M. Hol,Elly M. Hol,Jörg Hamann,Jörg Hamann,Inge Huitinga +11 more
TL;DR: The gene expression profile of different aspects of MS pathology is provided and indicates that early demyelination, mediated by scavenger receptors, is already present in regions around active MS lesions.
Treatment with anti-CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats.
TL;DR: It is suggested that CR3 plays a role in the recruitment of macrophages towards the inflamed CNS of EAE animals, and the role ofmacrophage adherence to the endothelium is confirmed in the generation of clinical signs of E AE.
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