Inge Hoebeke
Ghent University
9 Papers
5 Citations
Inge Hoebeke is an academic researcher from Ghent University. The author has contributed to research in topics: Stem cell & CD34. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Inge Hoebeke include Ghent University Hospital.
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Papers
Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment.
TL;DR: It is shown that human cord blood CD34(+)38(-)Lin- progenitor cells when co-cultured with the murine stromal cell line OP9-DL engineered to express the Notch ligand delta-like-1 mature into T lymphocytes with a phenotypic progression as the one seen in thymus.
137
Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment
TL;DR: It is indicated that Notch signaling is crucial to direct human progenitor cells into the T-cell lineage, whereas it has a negative impact on B, NK, and monocytic/dendritic cell generation in a dose-dependent fashion.
95
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38-CD7+ common lymphoid progenitors expressing lymphoid-specific genes
Inge Hoebeke,M De Smedt,F Stolz,F Stolz,Karin Pike-Overzet,Frank J. T. Staal,Jean Plum,Georges Leclercq +7 more
TL;DR: In this article, a candidate common lymphoid progenitor (CLP) has been isolated from CD34(+)CD38(-) human cord blood cells based on CD7 expression.
94
Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells
Inge Hoebeke,Magda De Smedt,Inge Van de Walle,Katia Reynvoet,Greet De Smet,Jean Plum,Georges Leclercq +6 more
TL;DR: These experiments indicate that HES-1 alone is not able to substitute for Notch-1 signaling to induce T-cell differentiation of human CD34+ hematopoietic stem cells.
21
Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies
Marjorie De Schryver,Hanne Van Gorp,Inge Hoebeke,Bauke De Maeyer,Karen Ooms,Isabel Pintelon,Louis Maes,Paul Cos,Hans Nauwynck,Peter Delputte +9 more
TL;DR: The newly developed mAbs can be used as novel tools for Sn research and further analysis of Sn internalization in different species and both species-specific and cross-reactive antibodies could be identified.
6