Inessa Halets
National Academy of Sciences of Belarus
7 Papers
170 Citations
Inessa Halets is an academic researcher from National Academy of Sciences of Belarus. The author has contributed to research in topics: Dendrimer & Human serum albumin. The author has an hindex of 6, co-authored 7 publications.
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Papers
How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo.
Dzmitry Shcharbin,Anna Janaszewska,Barbara Klajnert-Maculewicz,Barbara Ziemba,Volha Dzmitruk,Inessa Halets,Svetlana Loznikova,Natallia Shcharbina,Katarzyna Milowska,Maksim Ionov,Antos Shakhbazau,Maria Bryszewska +11 more
TL;DR: Promising results from in vivo studies open up the possibility of dendrimers being applied as a new generation of nano-therapeutic agents in medicine, especially in human gene therapy.
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Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (A). Mechanisms of interaction.
Maksim Ionov,Joanna Lazniewska,Volha Dzmitruk,Inessa Halets,Svetlana Loznikova,D. S. Novopashina,Evgeny K. Apartsin,Olga A. Krasheninina,Alya G. Venyaminova,Katarzyna Milowska,Olga Nowacka,Rafael Gomez-Ramirez,Francisco Javier de la Mata,Jean-Pierre Majoral,Dzmitry Shcharbin,Maria Bryszewska +15 more
TL;DR: The results indicate that siRNAs form complexes with all the dendrimers tested and that Oligoribonucleotide duplexes can be released from dendriplexes after heparin treatment and the structure of siRNA is maintained in the case of PAMAM or carbosilane d endrimers.
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Influence of fourth generation poly(propyleneimine) dendrimers on blood cells.
Barbara Ziemba,Inessa Halets,Dzmitry Shcharbin,Dietmar Appelhans,Brigitte Voit,Ireneusz Pieszyński,Maria Bryszewska,Barbara Klajnert +7 more
TL;DR: Although all dendrimers examined affected all the blood cells studied, the unmodified PPI-g4 had the most damaging effect, which caused high RBC haemolysis rates and PLT aggregation and greatly inhibited lymphocyte proliferation.
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Contribution of hydrophobicity, DNA and proteins to the cytotoxicity of cationic PAMAM dendrimers.
TL;DR: Interaction of PAMAM-NH2-C12(25%) G4 dendrimer with blood proteins and calf thymus DNA significantly reduced their cytotoxicity toward red blood cells.
21
Impact of maltose modified poly(propylene imine) dendrimers on liver alcohol dehydrogenase (LADH) internal dynamics and structure
Michal Ciolkowski,Inessa Halets,Dzmitry Shcharbin,Dietmar Appelhans,Brigitte Voit,Barbara Klajnert,Maria Bryszewska +6 more
TL;DR: In this paper, the ability of poly(propylene imine) dendrimers with surface modified with maltose moieties to interact with horse liver alcohol dehydrogenase (LADH) was examined.