our aims were: (1) to determine the MDR1 methylation levels in tissue of prostate cancer (pca), high grade prostatic intraepithelial neoplasia (Hgpin), benign prostatic hyperplasia (bpH) and morphologically normal prostate tissue (mnp); (2) to correlate the methylation levels of the MDR1 promoter with the immunoexpression of p-gp. our results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of p-gp expression regulation. Future studies will be able to evaluate the impact of these results in the treatment of pca patients. KEy-WORDS: prostate cancer; MDR1; p-gp; promoter methylation; epigenetics.

https://bdigital.ufp.pt/bitstream/10284/939/2/124-132.pdf

Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples

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Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples