Ines Leonhardt
Schiller International University
7 Papers
Ines Leonhardt is an academic researcher from Schiller International University. The author has contributed to research in topics: Candida albicans & Innate immune system. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Farnesol signalling in Candida albicans - more than just communication
TL;DR: An overview of the currently known aspects of farnesol production, sensing and action within C. albicans is provided and the characteristic of C.Albicans to simultaneously produce and tolerate highfarnesol concentrations that are lethal to other microbes is illustrated.
80
CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells
Sabrina Ziegler,Esther Weiss,Anna Schmitt,Jan Schlegel,Anne Burgert,Ulrich Terpitz,Markus Sauer,Lorenzo Moretta,Simona Sivori,Ines Leonhardt,Oliver Kurzai,Hermann Einsele,Juergen Loeffler +12 more
TL;DR: The direct interaction of NK cells and A. fumigatus was confirmed, leading to the conclusion that CD56 is a pathogen recognition receptor, which gives new insights into the functional role of CD56 in the pathogenic recognition during the innate immune response.
Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients.
Sandra Timme,Sandra Timme,Teresa Lehnert,Maria T. E. Prauße,Maria T. E. Prauße,Kerstin Hünniger,Kerstin Hünniger,Ines Leonhardt,Oliver Kurzai,Oliver Kurzai,Marc Thilo Figge,Marc Thilo Figge +11 more
TL;DR: Investigation of the innate immune response during blood stream infections with the two fungal pathogens C. albicans and C. glabrata reveals that these fungal infections in neutropenic patients can be successfully cleared by cytokine treatment of the remaining neutrophils; and that this treatment is more effective for C.glabRata than forC.
The Arthroderma benhamiae Hydrophobin HypA Mediates Hydrophobicity and Influences Recognition by Human Immune Effector Cells
Christoph Heddergott,Christoph Heddergott,Sandra Bruns,Sandra Bruns,Sandor Nietzsche,Ines Leonhardt,Oliver Kurzai,Olaf Kniemeyer,Olaf Kniemeyer,Axel A. Brakhage,Axel A. Brakhage +10 more
TL;DR: Cell wall-associated surface proteins were studied and suggested that the recognition of A. benhamiae by the cellular immune defense system is notably influenced by the presence of the surface rodlet layer formed by the hydrophobin HypA.
Host response to Candida albicans bloodstream infection and sepsis
TL;DR: The models used to study innate immune responses during Candida bloodstream infection, which includes protective immunity as well as harmful responses resulting in Candida induced sepsis are outlined and a thorough understanding of these mechanisms will help in creating an individualized approach to patients suffering from systemic candidiasis and aid in optimizing clinical management.