Ina M. Berger
University of Ulm
7 Papers
27 Citations
Ina M. Berger is an academic researcher from University of Ulm. The author has contributed to research in topics: Positional cloning & Biology. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Ina M. Berger include Heidelberg University & University Hospital Heidelberg.
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Papers
The myosin-interacting protein SMYD1 is essential for sarcomere organization.
Steffen Just,Benjamin Meder,Ina M. Berger,Christelle Etard,Nicole Trano,Eva Patzel,David Hassel,Sabine Marquart,Tillman Dahme,Britta Vogel,Mark C. Fishman,Hugo A. Katus,Uwe Strähle,Wolfgang Rottbauer +13 more
TL;DR: Although the zebrafish mutant flatline (fla) shows transcript levels of thick filament chaperones, such as Hsp90a1 and UNC-45b, to be severely upregulated in fla, its histone methyltransferase activity – mainly responsible for the nuclear function of SMYD1 – is dispensable for sarcomerogenesis.
Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Kerstin Hein,Kerstin Hein,Gerhard Mittler,Gerhard Mittler,Wiebke Cizelsky,Michael Kühl,Francesca Ferrante,Robert Liefke,Ina M. Berger,Steffen Just,J. Eric Sträng,Hans A. Kestler,Hans A. Kestler,Franz Oswald,Tilman Borggrefe,Tilman Borggrefe +15 more
TL;DR: It is found that the methyltransferase CARM1 methylated NICD at five conserved arginine residues within the C-terminal transactivation domain, which is important for its transcriptional activity and protein turnover.
In-vivo characterization of human dilated cardiomyopathy genes in zebrafish.
Britta Vogel,Benjamin Meder,Steffen Just,Christina Laufer,Ina M. Berger,Sabrina Weber,Hugo A. Katus,Wolfgang Rottbauer +7 more
TL;DR: The results indicate that the zebrafish is a suitable model organism to rapidly evaluate novel DCM disease genes in-vivo and gene-specific differences which are also seen in human DCM can be reliably reproduced in theZebrafish model.
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F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo
Sebastian Spaich,Rainer Will,Steffen Just,Saskia Spaich,Christian Kuhn,Derk Frank,Ina M. Berger,Stefan Wiemann,Bernhard Korn,Manfred Koegl,Johannes Backs,Hugo A. Katus,Wolfgang Rottbauer,Norbert Frey +13 more
TL;DR: In this paper, a bioinformatic approach to identify novel cardiac-enriched sarcomere proteins was used to identify F-box and leucine-rich repeat protein 22 (Fbxl22).
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Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity
Steffen Just,Ina M. Berger,Benjamin Meder,Johannes Backs,Andreas Keller,Sabine Marquart,Karen S. Frese,Eva Patzel,Gerd-Jörg Rauch,Hugo A. Katus,Wolfgang Rottbauer +10 more
TL;DR: In this article, a missense mutation in zebrafish protein kinase D2 (pkd2) was found to selectively perturb valve formation in the embryonic heart by abrogating endocardial Notch signaling in cardiac cushions.
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