Ildiko Toma
Stanford University
6 Papers
14 Citations
Ildiko Toma is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Mesenchymal stem cell. The author has an hindex of 4, co-authored 6 publications.
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Papers
Direct Evaluation of Myocardial Viability and Stem Cell Engraftment Demonstrates Salvage of the Injured Myocardium
Paul J Kim,Morteza Mahmoudi,Xiaohu Ge,Yuka Matsuura,Ildiko Toma,Scott A. Metzler,Nigel G. Kooreman,John Ramunas,Colin Holbrook,Michael V. McConnell,Helen M. Blau,Phillip Harnish,Eric Rulifson,Phillip C. Yang +13 more
TL;DR: The functional restoration seen in MiPSCs was characterized by increased myocardial viability and sustained engraftment without de novo cardiac differentiation, indicating salvage of the injured myocardium.
Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region
Ildiko Toma,Paul J Kim,Rajesh Dash,Michael V. McConnell,Dwight G. Nishimura,Phillip Harnish,Phillip C. Yang +6 more
TL;DR: The improved cardiac function in ischemic cardiomyopathy of diabetic mice by telmisartan is attributed to the attenuation of the peri-infarct injury by the angiogenic effects of EPCs to salvage the injuredCardiomyocytes.
Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model
Rajesh Dash,Ildiko Toma,Fumiaki Ikeno,Jennifer Lyons,Shahriar Heidary,Marie-Claude Parent,I-Ning E. Wang,Xiaohu Ge,Jaehoon Chung,Justin Lam,Paul J Kim,Kaori Nakagawa,Svetlana Lyalina,Grace Do,Robert C. Robbins,Michael V. McConnell,Alan C. Yeung,Phillip Harnish,Phillip C. Yang +18 more
TL;DR: Human Amnion-derived Mesenchymal Stem Cells were transplanted into the infarct and periinfarct regions of a pig ischemia-reperfusion model and improved cardiac systolic function post-MI, and Cardiac MRI with Manganese-Enhanced MRI was able to detect increased CNR from live populations of hAMSCs.
Manganese-enhanced MRI in the evaluation of cell-based therapy for myocardial restoration
TL;DR: A trend towards improved LVEF with ESC-RGs transplanted hearts, consistent with the results of this group’s previously published data, may support the hypothesis that functional improvement with stem cell therapy may be due to myocardial salvage.
•Journal Article
Abstract 18108: Performing Dual Contrast Cardiac MRI to Determine the Underlying Mechanism of Cell-based Therapy
TL;DR: The MiPSCs demonstrate the most significant functional restoration and may suggest myocardial regeneration as the mechanism for the sustained benefit of cardiac restorative effects.
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